Senior Scientist / Principal Scientist: Immunology / Immuno-Oncology

Job Summary: 

Kernal is seeking a Senior Scientist / Principal Scientist who wishes to play a key role in advancing novel CAR-T mRNA-LNP immunotherapy drug candidates to the clinic. The ideal candidate will act as resource in Immunology / Immuno-Oncology across the organization and is looking to make an impact in a biotech startup environment.

Responsibilities: 

• Responsible for initiating, planning and executing experiments that supports projects relevant to autoimmune diseases and cancer immunotherapy
• Perform various in vitro and ex-vivo assays utilizing cellular, molecular and translational biology techniques. 
• Must be excited to work at the bench.
• Design and executing in vivo studies to assess preclinical efficacy of Kernal proprietary targeted mRNA LNPs
• Instrumental in establishing a PK/PD/Efficacy relationship and biomarker identification
• Perform routine mammalian cell culture and transfection.
• Generate, analyze and interpret research data and oversee proper documentation by maintaining up-to-date electronic laboratory notebook records and communicate results to team members in written technical reports and oral presentations.
• Present experimental results to team members, management and at scientific conferences.
• Supervise and mentor junior staff

Requirements: 

• Doctorate in Immunology, Immuno-oncology or relevant scientific discipline with a strong publication record.
• Experience post Ph.D. in pharmaceutical or biotechnology settings is highly desired.  2+ (Senior Scientist), 5+ years (Principal Scientist)
• Expertise in drug discovery in immuno-oncology / immunology related projects
• Experience in biochemical and cell-based assays (FACS, Flow cytometry, Western blot, ELISA, single cell RNAseq, qPCR, ICS etc…)
• Expertise with auto-immune and/or tumor models (EAE, syngeneic, GEMM, humanized)
• Ability to work in a fast-paced environment with ambitious goals in a growing biotech

Benefits:

• Competitive compensation package
• Excellent healthcare coverage  
• Highly competitive 401(k)  
• Flexible Spending Account (FSA) 
• Generous vacation and sick days
• Paid parental leave, family caregiver leave, medical leave  
• Comprehensive insurance coverage 
• On-site cafe with complementary snacks and drinks  
• Monthly subway pass, or a subsidized commuter rail pass  
• Free MIT athletics gym membership
• Free Bluebikes membership  

Kernal is dedicated to providing a diverse work environment and is committed to equal employment opportunities for all its employees and qualified applicants. We do not discriminate in employment practices for reasons of race, color, national origin, age, gender, sexual orientation, marital or veteran status, religion, disability, or any other legally protected status. Kernal will provide reasonable accommodation for qualified individuals with known disabilities in accordance with applicable law.