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Associate Director of In Vivo Pharmacology

Piscataway, New Jersey, United States

Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy. 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Associate Director of In Vivo Pharmacology as part of the Research & Development team based in Piscataway, NJ. 

Role Overview

This position will perform preclinical and IND-enabling in vivo pharmacology and toxicology studies to support pipeline programs. The ideal candidate will have knowledge and experience in immunology or immune-oncology and in vivo study with mouse and NHP. The successful candidate will work in a collaborative environment and would be skillful in driving multiple projects by contributing to the development of cell-based immunotherapies.

Key Responsibilities  

  • Conduct in vivo studies with mice and NHP to assess CAR-T/NK mediated efficacy and toxicity with disease models of tumor or autoimmune disease. This includes designing and implementing in vivo pharmacology studies to support early-stage research programs and late-stage IND-enabling studies
  • Interact with and manage CROs for in vivo study related activities
  • Interact and collaborate with research teams for in vivo pharmacology and toxicology studies
  • Process and analyze tumor and tissues samples from mice and NHP
  • Assess safety and tox risks of cell-based drug products
  • Analyze, document and report all experiment findings
  • Perform additional exploratory and investigational studies with various techniques

Requirements

  • Ph.D. or master’s degree in biological sciences (Immunology, cell biology and cancer biology) or related area
  • Extensive hands-on in vivo study experience (5 years. Expertise in various injection, bleeding, tissue collection and processing)
  • Extensive knowledge and experience in immune cell function analysis and profiling with multi-color flow cytometry, cell coculture and other technologies
  • Prior experience in CAR-T/NK cell therapy development
  • Three or more year’s leadership experience in an environment of Biotech or pharmaceutical industry
  • Basic toxicology knowledge and experience
  • Strong critical thinking and problem-solving skills
  • Sense of ownership and integrity of their work
  • A demonstrated ability to work as part of a team
  • Preferred Language: Fluent in both English and Mandarin (verbal and written)

#Li-JK1

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.

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