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Scientist, In Vivo CAR-T

Philadelphia, PA

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.  

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

 

Legend Biotech is seeking a Scientist, In Vivo CAR-T as part of the R&D team based in Philadelphia, PA. 

Role Overview

Legend Biotechnology is at the forefront of developing innovative cell-based therapies. We are seeking an experienced and dynamic senior scientist to support our in vivo CAR-T cell therapy program. If you're passionate about advancing groundbreaking treatments and have a strong background in cellular immunotherapy, this role is for you.

The successful candidate should possess extensive knowledge and research experience in virology, molecular biology, CAR-T cell therapy. The candidate will be able to contribute to in vivo cell therapy platform and pipeline development through lentivirus preparation, ex vivo and in vitro function assays to evaluate product potency and safety. 2-3 year biotech or pharmaceutical industry or postdoc experience is required.

You will collaborate with team members and cross-functional teams, including research, development, and manufacturing, to drive the successful translation of preclinical findings into clinical applications. Your expertise will be critical in advancing our mission to improve patient outcomes.

 The candidate needs to demonstrate the ability of delivering scientific results with integrity and timeline, show the value of collaboration and teamwork, and provide expertise and team support in a fast-paced environment.

Key Responsibilities   

  • Develop cell and gene therapy platform and optimize cell-based immunoassays, including immune cell isolation and expansion, T cell culture, virus packaging and titering, multi-color flow cytometry, ELISA, cytotoxic assays, PCR analysis.
  • Work closely with team to test different designs to deliver reliable and consistent data
  • Independently design and execute experiments, document and interpret scientific results, present the data within research team and cross-functional teams
  • Experience to support project from early research to clinical stage is a plus
  • Stay alert to industry development, keep learning and be comfortable in a fast-paced team
  • Lab support work

Requirements

  • PhD in Immunology / cell biology, or master with extensive experience.
  • Experience in immunology, cell and gene therapy is preferred.
  • Knowledge in cell biology, cell culture, and flow cytometry preferred.

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The anticipated base pay range for this is: $93,463 – $122,670 USD. 

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.

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