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Sr. Principal Scientist, Preclinical Development

Somerset, New Jersey, United States

Legend Biotech is seeking a Sr. Principal Scientist, Preclinical Development as part of the Early Drug Development team based in Somerset, NJ. 

Role Overview

As a part of Legend Biotech’s Early Drug Discovery (EDD) department, the preclinical scientist will perform IND-enabling pharmacology and toxicology studies to support pipeline programs. The ideal candidate will have experience in immunology or immune-oncology to assist preclinical cell therapy studies from discovery to first-in-human trials, and through marketing authorization. Furthermore, the successful candidate will work in a collaborative environment and would be skillful in driving multiple projects by contributing to the development of cell-based immunotherapies.

Key Responsibilities  

  • Interact and communicate with other EDD members and research teams to advance pipelines.
  • Develop and validate assays to support diverse projects from lead optimization to the conduct of preclinical pharmacology and toxicology studies for regulatory submission.
  • Culture human primary cell lines and cryopreserve them to create robust working cell banks for use in future in vitro studies.
  • Design, optimize, and execute in vitro and in vivo IND-enabling studies.
  • Create, review, and approve prospective standard operating procedures for in vitro and in vivo IND-enabling studies.
  • Record all experiments in an electronic laboratory notebook, report deviations, conduct data analysis, and results in a final study report.
  • Design and support animal studies to assess efficacy and safety of cell therapies.
  • Plan, manage and execute IND enabling studies; manger and track delivery timeline; write study report and communicate to preclinical rep timely for results
  • Engage in back-translational study activities to improve efficacy and safety of drug products

Requirements

  • Ph.D. with at least 5 years previous laboratory experience.
  • Work experience in immunology, cancer biology or related fields.
  • Knowledge and expertise in immuno-oncology of large molecules or cell therapy is a plus.
  • Strong scientific background with hands on experience in cellular and molecular biology techniques (e.g., flow cytometry, ELISA, cell culture and cytotoxicity assays, qPCR, Western Blot and others)
  • Demonstrated experiences working with in vivo CAR-T
  • Demonstrated track record of scientific contributions in peer-reviewed journals and symposia
  • Ability to manage multiple programs in parallel while delivering on key milestones
  • Knowledge of GLP and regulatory agencies is a plus
  • Ability to multi-task in a fast-paced, highly collaborative diverse team environment

#Li-JR1

#Li-Hybrid

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.

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