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Scientist II - In Vivo Pharmacology

Philadelphia, PA

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.  

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

 

Legend Biotech is seeking Scientist II - In Vivo Pharmacology as part of the Research & Early Development team based in Philadelphia, PA. 

Role Overview

This position will perform preclinical in vivo pharmacology and toxicology studies to support pipeline programs. The ideal candidate will have experience in immunology or immune-oncology and in vivo studies with animal models. The successful candidate will work in a collaborative environment and is skillful in driving multiple projects by contributing to the development of cell-based immunotherapies.

Key Responsibilities  

  • Work together with other team members to plan, design and execute in vivo studies with mice and NHP; process and analyze various samples, including blood, tumor and tissues from mice and NHP
  • Manage mouse colonies, maintain instruments in animal facility for example IVIS imagine machine
  • Cell culture and immune cell functional analysis in vitro and in vivo
  • Interact with research teams for collaboration
  • Participate in assay development and qualification

Requirements

  • Master’s or bachelor’s degree in biological sciences (Immunology, cell biology and cancer biology) or related area
  • At least Five years’ laboratory experience. Extensive hands-on in vivo study experience is required. Expertise in various injections, especially in tail vein injection, bleeding, in vivo imaging, tissue collection and processing.
  • Extensive experience in execution of T cell functional analysis and multi-color flow cytometry assays is required.
  • Molecular biology skills such as DNA and RNA extraction, RT-PCR and ddPCR, etc.
  • Prior experience in CAR-T/NK cell therapy development is preferred. Experience in lentivirus production is a plus
  • Sense of ownership and integrity of their work. Demonstrated ability to work as part of a team
  • Demonstrated organizational skills including but not limited to pay attention to details and multitasking
  • Biotech or pharmaceutical industry experience is preferred.
  • Expertise in in vivo and in vitro studies, excellent mouse tail vein injection skill, flow cytometry, ELISA, tissue culture/primary cell culture, cytotoxicity assays, qPCR, and multiplexed cytokine analysis assays (MSD and Luminex).
  • Excellent verbal and written communication skills in English

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The anticipated base pay range is:

$107,482 - $141,070 USD

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.

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