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Scientist

Philadelphia, PA

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.  

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

 

Legend Biotech is seeking Scientist as part of the Exploratory Technology team based in Philadelphia, PA. 

Role Overview

We are seeking a R&D scientist (Pipeline support) who possesses extensive knowledge and research experience in lentivirus production and cell immunotherapy to support our in vivo CAR T cell therapy program. The candidate is responsible for contributing to in vivo CAR delivery platform optimization and pipeline development.

Key Responsibilities  

  • Produce research grade lentivirus to support in vitro studies performed in the R&D team
  • Perform lentivirus titering such as p24 ELISA and qPCR
  • Setup in vitro CAR T cell culture, characterization and functional assays including PBMC culture, T cell isolation and expansion, multi-color flow cytometry, cytotoxic assays (e.g. IncuCyte), cytokine detection (e.g. MSD) and VCN analysis.
  • Independently design and execute experiments and at the same time, work closely with the team and cross-functional teams in a highly collaborative environment
  • Deliver reliable and consistent data and be able to interpret scientific results and present the data within research team and cross-functional teams
  • Complete ELN in a timely manner with good documentation skills.
  • Support laboratory chores as a good team player
  • Experience to support project from early research to clinical stage is a plus
  • Stay alert to industry development, keep learning and be comfortable in a fast-paced team
  • Has the authority to make decisions related to technical direction, methodologies, approaches for experiment setup.

Requirements

  • PhD in biological sciences such as Immunology, Cell biology and Biochemistry.
  • 2 – 3 years postdoc experience. Experience in biotech companies is a plus.
  • IT Skills: Microsoft office, Flowjo, GraphPad Prism.

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The anticipated base pay range is:

$93,463 - $122,670 USD

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.

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