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Scientist II

Somerset, New Jersey, United States

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

 

Legend Biotech is seeking Scientist II as part of the Manufacturing Technology team based in Somerset, NJ. 

Role Overview

We are seeking an experienced Scientist II to join our MSAT team, responsible for driving the development, implementation, and optimization of innovative manufacturing processes for autologous and allogeneic cellular therapy products, including CAR-T. You will lead the design, execution, and interpretation of complex process development experiments, collaborate with cross-functional teams, and ensure seamless technology transfers to GMP manufacturing groups

Key Responsibilities  

  • Lead the development of automated manufacturing processes, including cell selection, activation, expansion, and harvest
  • Design, execute, and interpret complex process development experiments
  • Author, review, and coordinate technical documents, protocols, and reports
  • Analyze and present data in a clear and concise manner
  • Ensure GMP compliance in laboratory notebooks, protocols, and reports
  • Collaborate with internal and external partners to evaluate, develop, and implement new process technologies
  • Author technical documents to support regulatory filings
  • Conduct technical discussions & meetings with internal stakeholders including procurement, quality, development and finance, and facilitate implementation of new automated processes
  • Provide technical leadership and mentorship to junior team members
  • Design and execute proof-of-concept experiments to demonstrate feasibility of new technologies or processes
  • Generate and analyze data to demonstrate compatibility of new technologies or processes with existing manufacturing systems
  • Lead technology transfer activities to ensure successful implementation of new processes or technologies in GMP manufacturing environments
  • Make independent decisions regarding routine laboratory execution, minor troubleshooting, and data analysis within approved study protocols. Guidance is sought from senior team members for experimental design, major troubleshooting steps, and changes to validated processes.

Requirements

  • PhD, MS, or BS in Cell Biology, Immunology, Biomedical Engineering, or other related discipline.
  • 5-7 years of experience in MSAT, process development, or a related field
  • Strong expertise in cell therapy, automation, and bioprocessing
  • Excellent leadership, communication, and project management skills
  • Experience with technology transfers, GMP manufacturing, and regulatory filings
  • Ability to work effectively in a fast-paced, dynamic environment
  • Knowledge of automation technologies, including but not limited to:
  • Experience with GMP implementation, including but not limited to:
    • GMP regulations and guidelines
    • Quality management systems
    • Process validation and verification
  • Experience with CAR-T cell therapy or similar cellular therapy products
  • Knowledge of regulatory requirements for cellular therapy products
  • Familiarity with design of experiments (DOE) and statistical process control (SPC)

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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

 

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

 

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

 
For information related to our privacy notice, please review: Legend Biotech Privacy Notice.

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I (the candidate) enter into this Non-Disclosure Agreement (the “Agreement”) with Legend Biotech USA Inc. (the “Company”), effective as of the date of my acknowledgement below, for the purpose of enabling the Company to evaluate a possible employment relationship with me.

  1. Access to Company Confidential Information. I acknowledge that for the sole and limited purpose of evaluating a possible employment relationship with me, the Company might disclose, or enable me to have access to, certain Confidential Information of the Company, as defined below.  I agree that, except for purposes of evaluating a possible employment relationship with the Company or as expressly authorized in writing by the Company, I will (a) not use or disclose any Confidential Information; (b) keep all Confidential Information confidential at all times; and (c) not copy, reproduce or modify any Confidential Information.
  2. Definition of “Confidential Information.” For purposes of this Agreement, “Confidential Information” shall mean any and all information and materials provided to me by the Company, including without limitation, inventions, trade secrets, software code, product development and marketing strategies, ideas, processes, formulas, know-how, unpublished financial information, business plans, contractual relationships with third parties and operating strategies; memoranda, notes, records, drawings, manuals, disks, or other documents and media; and all embodiments, copies, extracts, and summaries thereof; provided, however, that “Confidential Information” shall not include information that: (a) is generally known or available to the public, or (b) is furnished to me by a third party who obtained such information using lawful means and without any restrictions on disclosure.
  3. Third Party Information. I agree that during the course of communications with the Company pursuant to this Agreement or in connection with my application and interviews for employment with the Company, I will not make any unauthorized use or disclosure to the Company of any confidential or proprietary information or trade secrets of any other person or entity to whom I have an obligation of confidentiality with respect to such information, including any current or former employer.  I further agree not to provide to the Company any materials or documents of any third party that are not generally available to the public.
  4. Remedies for Breach. I acknowledge that in the event of any breach of this Agreement, the Company will not have an adequate remedy in money or damages, and therefore the Company shall be entitled to obtain temporary, preliminary and/or permanent injunctive relief to redress any such breach, from any court of competent jurisdiction, and that the Company’s right to obtain such relief shall not limit its right to obtain other available remedies.
  5. General. The interpretation and enforcement of this Agreement shall be governed by the laws of the State of California.  This Agreement constitutes the entire agreement between the parties concerning the subject matters hereof; it supersedes any and all prior agreements or representations, written or oral, with respect to its subject matters; and it cannot be modified except in a written agreement signed by the Company.

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