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Associate Director, Translational Science

Somerset, New Jersey, United States

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

 

Legend Biotech is seeking an Associate Director, Translational Science as part of the Early Drug Development team based in Somerset, NJ.

 

Role Overview

The Associate Director of Translational Science will bridge the gap between early-stage discovery research and clinical development. This role requires a unique blend of deep immunological expertise and advanced computational proficiency. You will be responsible for designing and executing translational strategies, identifying biomarkers, and leveraging large-scale multi-omic datasets to provide actionable insights into mechanism of action (MoA), patient stratification, and drug resistance in both autoimmune and oncology disease area.

 

Key Responsibilities

  • Translational Strategy: Lead the development and execution of program-specific translational plans from lead optimization through Phase II clinical trials.
  • Data Integration & Analysis: Oversee the analysis of high-dimensional datasets (e.g., scRNA-seq, CITE-seq, flow cytometry, and spatial transcriptomics) to identify pharmacodynamic markers and predictive signatures, to interpret and provide insight into the biological mechanisms.
  • Clinical Collaboration: Partner with Clinical Development and Clinical Operations to implement biomarker assays in clinical protocols and ensure high-quality data collection.
  • External Partnerships: Manage relationships with Contract Research Organizations (CROs) and academic collaborators for specialized assay development and advanced data processing.
  • Cross-Functional Leadership: Represent Translational Science on program teams, providing expert input on disease biology, target engagement, and competitive landscape.
  • Scientific Communication: Author high-quality technical reports, regulatory documents (IND/IB/NDA), and contribute to peer-reviewed publications and conference presentations.

 

Requirements

  • PhD or MD/PhD in Immunology, Bioinformatics, Computational Biology, or a related field.
  •  5+ years of experience in the biopharmaceutical industry or an equivalent academic leadership role within translational research.
  • Extensive knowledge of human auto-immune disease and oncology diseases, specifically in areas such as immuno-oncology, autoimmune diseases, or cell therapy (CAR-T/TCR-T).
  • Demonstrated experience with genomic data analysis. Practical and hand on experience data analysis pipeline, ability to guide data integration, knowledge integration from multiple datasets is essential.
  • Proven track record in the development, validation, and clinical implementation of complex biomarkers.
  • Experience working with relevant disease areas, deep understanding of the biological mechanisms related to diseases(auto-immune, oncology, or/both).
  • Strong understanding of regulatory requirements for biomarker-driven clinical trials.
  • Excellent project management skills with the ability to lead multiple programs in a fast-paced environment.
  • High scientific curiosity, driven, motivated in deep understanding of the biology behind both disease and therapies.

 

#Li-AS1

#Li-Hybrid

The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.

Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles.

Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Pay Range (Base Pay):

$168,372 - $220,988 USD

Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

 

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

 

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

 
For information related to our privacy notice, please review: Legend Biotech Privacy Notice.

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I (the candidate) enter into this Non-Disclosure Agreement (the “Agreement”) with Legend Biotech USA Inc. (the “Company”), effective as of the date of my acknowledgement below, for the purpose of enabling the Company to evaluate a possible employment relationship with me.

  1. Access to Company Confidential Information. I acknowledge that for the sole and limited purpose of evaluating a possible employment relationship with me, the Company might disclose, or enable me to have access to, certain Confidential Information of the Company, as defined below.  I agree that, except for purposes of evaluating a possible employment relationship with the Company or as expressly authorized in writing by the Company, I will (a) not use or disclose any Confidential Information; (b) keep all Confidential Information confidential at all times; and (c) not copy, reproduce or modify any Confidential Information.
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  4. Remedies for Breach. I acknowledge that in the event of any breach of this Agreement, the Company will not have an adequate remedy in money or damages, and therefore the Company shall be entitled to obtain temporary, preliminary and/or permanent injunctive relief to redress any such breach, from any court of competent jurisdiction, and that the Company’s right to obtain such relief shall not limit its right to obtain other available remedies.
  5. General. The interpretation and enforcement of this Agreement shall be governed by the laws of the State of California.  This Agreement constitutes the entire agreement between the parties concerning the subject matters hereof; it supersedes any and all prior agreements or representations, written or oral, with respect to its subject matters; and it cannot be modified except in a written agreement signed by the Company.

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