Senior Research Associate, Translational Biology and Assay Development

About Lila

Lila Sciences is the world’s first scientific superintelligence platform and autonomous lab for life, chemistry, and materials science.  We are pioneering a new age of boundless discovery by building the capabilities to apply AI to every aspect of the scientific method.  We are introducing scientific superintelligence to solve humankind's greatest challenges, enabling scientists to bring forth solutions in human health, climate, and sustainability at a pace and scale never experienced before. Learn more about this mission at  www.lila.ai

If this sounds like an environment you’d love to work in, even if you only have some of the experience listed below, we encourage you to apply.

Your Impact at Lila

As a Senior Research Associate, your contributions will be pivotal in shaping the future of Lila Sciences' LNP-RNA therapies. You will take lead ownership of our mammalian cell-based RNA expression and characterization, developing and implementing robust cell-based assays that generate the high-quality data required for informed decision-making and the successful progression of our pipeline. This is a hands-on role where your expertise directly translates into tangible advancements.

What You'll Be Building

• Execute RNA transfections (pooled and arrayed) in diverse primary and established mammalian cell models
• Apply molecular biology techniques including DNA/RNA extraction, qPCR, and RNA-seq for LNP-RNA expression and characterization
• Design, develop, and execute comprehensive mammalian cell-based assays for LNP-RNA therapeutic candidates, covering proliferation, cytotoxicity, potency, ADCC, ADCP, and immunotoxicity (T cell activation)
• Contribute to the development, optimization, and implementation of robust Standard Operating Procedures (SOPs) for assay scale-up and automation
• Operate and troubleshoot automated equipment and high-throughput platforms, including liquid handlers, plate readers, flow cytometers (FACS), and high-content imagers
• Foster strong cross-functional collaboration, perform rigorous data analysis and interpretation (Python proficiency beneficial), and efficiently manage multiple concurrent projects

What You’ll Need to Succeed

• Education & Experience: MS with 2+ years or BS with 4+ years of relevant industry experience in Cell Biology, Immunology, Biotechnology, Molecular Biology, or a related field.
• Cell Culture & Transfection: Extensive hands-on experience with diverse mammalian cell lines, primary cells, PBMCs, and established complex cell lines. Proficiency in high-throughput DNA/RNA transfections.
• Assay Development: Demonstrated expertise in developing and executing a broad range of in vitro functional assays, including T cell activation and proliferation, cytotoxicity, potency, ADCC, and standard immunoassays (e.g., ELISA, MSD) to support R&D and CMC initiatives.
• Molecular Biology: Proven experience with RNA characterization assays, applying molecular biology techniques such as RNA extraction, qPCR, and RNA-seq.
• Automation & High-Throughput: Practical experience operating automated liquid handlers, plate readers, and flow cytometers (FACS). Familiarity with SOP development for assay scale-up.
• Data Analysis: Strong analytical skills for interpreting complex biological data.
• Collaboration & Adaptability: Excellent communication and cross-functional collaboration skills; ability to thrive in a dynamic, fast-paced, multi-project environment.

Bonus Points For

• Experience with stem cell culture and differentiation techniques.
• Exposure to Python for data analysis.
• Hands-on experience with high-content imaging systems for advanced cellular analysis.
• Familiarity or experience with gene editing, advanced sequencing and barcoding assays.

We’re All In

Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

A Note to Agencies

Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.