Back to jobs

Senior Manager, Flow Cytometry

South San Francisco, California, United States
Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response.  We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.
 

POSITION SUMMARY:

The individual in this role will be responsible for leading and maintaining operations of a state-of-the-art flow cytometry facility. The candidate will serve as a subject matter expert to pre-clinical research and translational sciences teams and support high-dimensional analysis of cellular phenotypes, high-speed cell sorting, assay development, workflows, troubleshooting and data analysis to address a diverse set of hypotheses related to CAR-T biology. The incumbent will manage all operational aspects of flow cytometry lab such as instrument maintenance and reagent/materials ordering. In addition, this role will nurture relationships with key project leads and internal stakeholders to ensure effective communication, collaboration and achievement of enterprise-level research objectives.

KEY ROLES AND RESPONSIBILITIES:

  • Partner closely with scientists in pre-clinical and translational teams to ensure the generation of high-quality, reliable, reproducible flow cytometry data through optimal panel design, assay development and analysis, while ensuring its positive impact on research objectives
  • Ensure the maintenance of flow cytometry analyzers and sorters at peak operating condition by ensuring ongoing instrument maintenance, standardization, and quality assurance
  • Manage/oversee research associates including mentoring, development, and training
  • Ensure successful assay development, execution, and smooth operations of the flow core by maintaining antibody and other critical reagent inventory
  • Responsible for writing and reviewing protocols and technical documents and ensuring quality standards are met in research laboratory setting
  • Establish and standardize analysis strategies for flow cytometry-based assays and work with IT team for efficient data handling and storage
  • Support cell sorting for downstream next-gen sequencing-based assays to enable deeper characterization of CAR-T cells in the context of complex in-vitro and in-vivo models
  • Work closely and maintain productive relationships with process sciences team on complex flow cytometry assays for T cell characterization. Nurture productive and collegial relationships with all users
  • Engage in continuing scientific and technical education so that the latest expertise knowledge is available to meet challenges in cutting-edge CAR-T research
  • Train and assist new users with technical and operational procedures

PREFERRED EDUCATION:

  • BSc in Immunology, Molecular and Cell Biology, Cancer Biology or related field with a minimum of 13 years’ experience or an 
  • MSc in Immunology, Molecular and Cell Biology, Cancer Biology or related field with a minimum of 11 years’ experience or a
  • PhD in Immunology, Molecular and Cell Biology, Cancer Biology or related field with a minimum of 6 years’ experience
  • Demonstrated understanding of, and ability to apply principles, concepts, practices and standards associated with analytical flow cytometry assay development/validation, panel design, and/or sample testing in a laboratory setting.
  • Proven experience in using high-dimensional multi-color flow cytometry instruments (Cytek Aurora preferable) and expert in multi-color panel design and analysis
  • Expert in FlowJo and proven experience in analysis strategies for flow cytometry-based assays (knowledge of R scripting language considered a plus
  • Demonstrated experience and understanding of techniques directly applicable to immune-oncology and/or CAR T research
  • Must have excellent oral and written communication and presentation skills
  • Must have critical thinking, high degree of ownership, strong organizational, and problem-solving skills and ability to quickly adapt to changing project
  • Self-motivated and driven to achieve milestones and exceed goals with minimal direction
  • Ability to work independently and collaboratively among cross-functional teams
  • Ability to work efficiently, prioritize workflow, meet deadlines and balance competing priorities
  • Excellent analytical skills and scientific/technical expertise
 
Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents.
 
The salary range for this position is $160,000 to $175,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.
 
Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown.
 
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
 
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Select...
Select...
Select...
Select...
Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Lyell Immunopharma’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.