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Scientist II or Sr. Scientist, Analytical Development

Seattle, Washington, United States

Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response.  We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency. 

 

Position Summary:

The Scientist II or Sr Scientist, Analytical Development (AD) will be responsible for leading a newly formed product characterization team within Analytical Development. The role and responsibilities would include but are not limited to characterizing drug products from Lyell’s manufacturing facility using flowcytometry, cell based and molecular methods to facilitate manufacturing success, process improvement, immunological interpretations and driving clinical correlations. The successful candidate will be responsible for leading the team and open to hands-on bench work. The role will encompass driving projects across various Lyell programs in close collaboration across TechOps, Research, Translational and Biometrics teams. The Scientist in this role will work closely with other members of the AD group to support development of characterization assays and transfer them to the product characterization team, mentor team members, review data, maintain high quality ELNs and contribute to IND filings.

 

The successful candidate will have expertise in cellular immunology, flowcytometry, cell-based and molecular assays with analytical testing methodologies and an understanding of the technological requirements to execute on testing and characterization needs of a cellular therapy company.

 

Essential Functions:

  • Design, develop, execute, and document flow cytometry/cell/molecular based analytical methods for product characterization and investigations.
  • Support product characterization activities, including comparability assessments in support of product life cycle management.
  • Partner in the transfer of qualified assays within AD and to QC, and support assay validation and investigations.
  • Develop and deliver scientific presentations, prepare clear and concise technical reports, participate in project teams as needed.
  • Participate in the evaluation of new analytical technologies and their implementation.
  • Provide analytical support to cross-functional project teams.
  • Revise, review, and author assay standard operating procedures and ELNs.
  • Contribute to building a culture that encourages continuous learning, improvement, and innovation, and encourages team members to expand their technical skill base.

Preferred Experience:

  • Scientist II - A minimum of 11 years of experience in immunology / cell biology, plus a Bachelors or 9 years of experience plus a Masters degree
  • Sr. Scientist I - A minimum of 10 years of extensive experience in immunology/ cell biology, plus a Phd
  • Previous people management experience preferred
  • Well versed in wide variety of analytical techniques such as cytotoxicity assays, flowcytometry, cytokine release assays, cell counting, short term cell culture and other applicable methods.
  • Experience in analytical development, cGMP QC testing and implementation of new technologies in a regulated environment.
  • Experience with assessment of new technologies in a fast-paced, learning organization preferably in a cross-functional setting where impact of new technologies is evaluated across research, development, and commercial organizations.
  • Prior experience in cell therapy development preferred.

 Preferred Additional Skills:

  • Must have excellent oral and written communication skills
  • Proven ability to work independently and collaboratively among cross-functional teams
  • Ability to work efficiently, prioritize workflow, meet deadlines and balance competing priorities
  • Excellent analytical skills and technical expertise
 
Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents.
 
The salary range for this position is $140,000 to $180,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.
 
Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown.
 
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
 
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.

 

Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include Flex Time off,  sick leave, 8 observed holidays as well as a floating holiday. We also have a winter office shutdown.

 

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.

 

We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.

 

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