Histotechnician - part time

Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response.  We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency. 

We are seeking an experienced, self-directed Histotechnician to manage tissue workflow from grossing through slide preparation and digital scanning. This role supports both animal and human tissue specimens and requires precision, efficiency, and full ownership of histology execution.

You will work closely with lab scientists and pathologists to ensure high-quality histologic preparation that supports research and study objectives.

Key Responsibilities

• Perform gross tissue processing and specimen handling
• Prepare tissues for FFPE processing and block embedding
• Prepare and embed cell pellet blocks
• Perform FFPE trimming and microtome sectioning (animal and human tissue)
• Perform frozen sectioning as needed
• Prepare unstained and H&E-stained slides
• Operate automated stainers, coverslippers, and digital slide scanners
• Maintain specimen labeling, tracking, and documentation
• Maintain and troubleshoot microtome, cryostat, tissue processor, and scanner
• Document procedures and results in ELN systems (e.g., Benchling)
• Generate organized records using Microsoft Word and Excel
• Partner with lab scientists and pathologists for slide review and quality control
• Contribute to SOP development and workflow optimization

Qualifications

• Associate’s or Bachelor’s degree in Histotechnology, Biology, or related field
• 15+ years hands-on histology experience
• HT or HTL certification preferred
• Demonstrated experience with:
• FFPE processing and embedding
• Human and animal tissue sectioning
• Cell pellet block preparation
• High-quality microtome sectioning
• H&E and other special staining procedures
• Digital slide scanning
• Strong understanding of tissue orientation and artifact prevention
• Independent, detail-oriented, and able to prioritize across projects
• Strong communication and problem-solving skills
• Comfortable working collaboratively in a research-driven laboratory environment

The salary range for this position is $51.00 per hour - $80.00 per hour with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.

Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include Flex Time off,  sick leave, 8 observed holidays as well as a floating holiday. We also have a winter office shutdown.

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.

We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.