Scientist II/Senior Scientist, Cell and Molecular Biology

About Magnet Biomedicine

Magnet is a biotechnology company pioneering the discovery of oral molecular glues - small molecules that induce proximity between proteins to modulate their function. Our proprietary TrueGlue(TM) platform is designed to address hard-to-drug targets across cancer and immune-mediated diseases.

With support from ARCH Venture Partners, Newpath Partners, Taiho Ventures, and Eli Lilly, Magnet is advancing internal programs in oncology, immunology, and inflammation. Magnet has also entered into a collaboration and license agreement with Eli Lilly to discover, develop, and commercialize specific molecular glue therapeutics in oncology.

Position Summary

We are seeking a highly motivated and hands-on biologist to join our team. In this position, you will play a pivotal role in designing, executing, and interpreting experiments to develop novel protein-protein interaction strategies that modulate target protein function. This is a unique opportunity to contribute to the development of next-generation therapeutics and make a significant impact on the biotechnology and pharmaceutical industries. 

The successful candidate will conduct phenotypic cell-based assays, enzymatic assays, and binding experiments while collaborating closely with a multidisciplinary team of scientists to discover and develop molecular glue therapeutics. The ideal candidate is scientifically curious, highly collaborative, and motivated to continuously expand their technical expertise while contributing to a fast-paced research environment. 

Key Responsibilities 

• Design and execute cellular and molecular biology experiments to support discovery programs.
• Evaluate protein-protein interactions using approaches such as NanoBiT, NanoBRET, IP-MS, ALPHAscreen, and related technologies.
• Experiment with human whole blood, human biopsies and/or lentivirus (BCL2+).
• Analyze experimental data, draw scientific conclusions, and communicate results to project teams and company colleagues.
• Maintain accurate and complete experimental records within the electronic laboratory notebook (ELN).
• Independently troubleshoot technical experimental challenges and seek input when appropriate.
• Collaborate closely with scientists across disciplines to solve scientific problems and advance research objectives.
• Continuously expand technical expertise and adopt new methodologies to support evolving research needs. 

Required Qualifications and Skills 

• PhD in Cell Biology, Molecular Biology, Biochemistry, Genetics, or a related discipline with 2-8 years of biotech experience; or BS/MS with 8+ years of industry experience, including biotech.
• Hands-on experience with small-molecule binding and inhibition assays.
• Strong experimental design, execution, and analytical skills.
• Strong analytical mindset and familiarity with relevant statistical methods.
• Experience working with human whole blood, human biopsies and/or lentivirus (BCL2+).
• Demonstrated scientific productivity through publications, presentations, or equivalent accomplishments.
• Proficiency with scientific data analysis and visualization software.
• Intellectual curiosity, scientific rigor, and a positive, collegial attitude.
• Willingness to learn new techniques and rapidly develop expertise in emerging technologies. 

Preferred Qualifications 

• Hands-on work with molecular glue therapeutics or targeted protein degradation approaches.
• Strong working knowledge in immunology or oncology.
• Experience utilizing confocal and fluorescence microscopy methodologies in drug discovery.
• Experience leveraging flow cytometry and cell-based screening platforms to support research and discovery efforts. 
• Demonstrated ability to oversee and collaborate with external CROs to achieve project objectives and timelines.