Sr. Research Associate / Associate Scientist, Protein Sciences

Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges. 

Manifold Bio is seeking a protein enthusiast to join our growing team pursuing our mission of multiplexed, in vivo drug discovery. The ideal candidate will have extensive experience in protein production focused on the generation of therapeutic constructs. This is a unique opportunity to own impactful projects and play an integral role on a small team looking to redefine current drug discovery paradigms. You will be an essential part in every step of our protein therapeutics work, from designing expression vectors to high-throughput and large-scale expressions, optimization of purification processes, full characterization suites, and formulation for in-vivo studies performed using candidates for clinical development. Further, you will focus on advancing protein production methodologies leveraging unique protein multiplexing technology we’ve developed at Manifold.   You will work closely with a collaborative, interdisciplinary team of scientists to design, execute, and analyze complex experiments in a fast-paced environment. There will be many opportunities for creativity, innovation, and ownership in this hands-on role leveraging our cutting edge platform to initiate and advance programs. Together, we’ll continue to build a transformational company based on the vision of  massively increasing the throughput of testing of protein therapeutic designs to fundamentally change the current paradigm of drug development.  

Responsibilities

• Independently design, plan and execute experiments to advance drug candidates and programs
• Work collaboratively as part of the Protein Sciences team to generate protein constructs for in-vivo studies
• Build on current cloning, expression, purification, and characterization methods to increase throughput
• Balance ownership of long-term innovation projects with construct production to advance pipelines 
• Contribute to lead validation experiments and prepare preclinical data packages 
• Stay up to speed on cutting edge research and industry standards for protein therapeutics
• Maintain data integrity and effectively communicate findings to the team

Required Qualifications

• B.S./M.S. in protein biochemistry, molecular biology, cell biology, bioengineering or similar with at least 3 years of experience. 
• Expertise in protein biochemistry, especially purification and characterization techniques
• Hands-on experience with mammalian cell culture for protein production
• Understanding binder-based protein analysis and in-vivo construct formulation
• Experience in cloning techniques and plasmid design/preparation
• Collaborative, curious, and flexible, with a genuine passion for innovative science and developing medicines
• Strong oral and/or written communication to facilitate complex experiments with multiple parties; excellent record keeping 

Preferred Qualifications

• 3+ years experience in pharma/biotech industry working on protein therapeutic drug programs
• Experience in protein production in the conent and techniques for binder-based constructs, such as BLI and SPR
• Experience with high-throughput protein expression and purification

Why you might be a good fit

• The idea of purifying protein is what gets you out of bed in the morning. 
• You’re excited about working with a wide scope of construct formats and moieties. 
• Team player with enthusiasm for working collaboratively to solve challenging problems
• Forethought, organization, and flexibility to meet deadlines and iterate in a fast-paced startup environment

If you’re excited to build a platform that combines DNA and protein multiplexing technologies, please apply! 

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.