Research Associate I/II - Biology
ABOUT THE COMPANY
Marea Therapeutics is a clinical-stage biotechnology company based in South San Francisco with a growing pipeline of first-in-class therapies to address genetically validated cardioendocrine disease targets. Our therapies have the potential to complement existing therapies and serve as transformative treatment options for significant patient populations living with cardioendocrine diseases.
Incubated by Third Rock Ventures, Marea completed a Series B financing in June 2024 and is well funded by a syndicate of leading life science investors including Sofinnova, Forbion, Xontogeny/ Perceptive Advisors, venBio, Omega Funds, Surveyor, Alpha Wave and Third Rock Ventures.
The company’s lead program, MAR001, is a monoclonal antibody targeting ANGPTL4, a genetically validated target with potential to address the subset of patients at the highest risk of adverse cardiovascular events, despite current standard of care therapies. MAR001 is rapidly progressing through Phase 2b clinical development. Our second clinical asset, MAR002, is a monoclonal antibody targeting excess growth hormone produced by the pituitary gland in the rare hormonal disorder, acromegaly. MAR002 has potential to become best-in-disease and is rapidly progressing through Phase 1 clinical development. We also have a third asset that is rapidly advancing through research discovery, with DC nomination expected next year.
At Marea, we believe in the power of collaboration and the importance of leading by example. We are a tight-knit team that values the contributions of every member, from interns to senior leaders. Our environment is dynamic, with each day presenting new challenges and opportunities for growth. Every role is “Hands-On”, and the successful candidate will be able to work alongside team members, regardless of level, to understand challenges and drive results.
ABOUT THE ROLE
We are seeking a highly motivated Research Associate with 2-4 years of experience with in-vitro molecular/cell-based assays to join our growing research team. This individual will work closely with the head of biology and other research team members in the execution of molecular, cellular, and ex vivo studies to support drug discovery and preclinical research. This is a great opportunity to gain deep exposure to therapeutics R&D and contribute to Marea’s pipeline. A good foundation in cell culture technique, experience working in a BSL2 lab environment and solid hands-on knowledge of a variety of in vitro/ex vivo assays is required. The ideal candidate will have scientific rigor, great interpersonal/collaboration skills, and outstanding work ethic.
This is a full-time, South San Francisco-based position with the expectation of working on-site 5 days per week.
KEY RESPONSIBILITIES
- Cell/tissue culture and processing
Execute workflows involving mammalian cell culture (including human/non-human primate primary cells), as well as processing of solid tissues and blood samples (e.g., PBMCs, serum, plasma). - High-throughput (96-/384-well) molecular biology and immune-based assays
Branched DNA assay, RT-qPCR, ELISA, Western blot, etc. from a variety of biological matrices.
Teamwork
Develop a solid understanding of the projects on hand to effectively collaborate with other research team members. - Scientific communication
Keep impeccable experimental and data records. Present results clearly to internal teams; contribute data to scientific publications, regulatory documents, and conference materials.
QUALIFICATIONS
- BS or MS in Life Sciences (e.g., Molecular Biology, Cell Biology, Biochemistry, Physiology, etc.)
- 2-4 years of post-graduate research experience in industry or academia
- Strong knowledge of cell culture aseptic technique and experience working in a BSL2 lab environment.
- Hands-on experience in a plethora of in vitro and cell-based assays (e.g., ELISA, RT-qPCR, Western blot, microscopy, etc.)
- Experience with biological data analysis software (e.g., GraphPad Prism, SoftMax Pro, FlowJo, etc.)
PREFERRED QUALIFICATIONS
- Track record of contributing to publications, presentations, or patents in an academic or industry setting
- Experience working in the fast-paced environment of biotech start-up
- Hands-on experience/certification in working with laboratory mice (handling, dosing, blood collection, tissue dissection)
PAY RANGE
The salary range for this role is $90,000 - $120,000. Compensation and title will be competitive and commensurate with the candidate's experience, qualifications, and responsibilities of the position.
WORKING CONDITIONS
- Laboratory based role, full time on-site
- Prolonged periods of work at a stationary lab bench or computer desk
- Occasional need to adjust, handle, or move objects up to 20 pounds
#LI-Hybrid
We do not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, disability, veteran status, marital status, or based on an individual’s status in any group or class protected by applicable federal, state, and local law. We invite applications from minorities, women, the disabled, protected veterans, and all other qualified applicants.
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