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Scientist, RNA Biology and Optimization

Emeryville, California, United States

Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. 

Whether it's the biological diversity of our gene editing systems or the people that help discover them, Metagenomi celebrates the diversity of life. This is achieved through a compassionate culture that acknowledges the dimensions of our diversity.  We know that when people feel a sense of inclusion and belonging in the workplace, they have a safe space to bring creativity and innovation to everything they do. We are intentional about building and maintaining a culture where people are valued and respected, there is equity in opportunities, and our respective opinions and differences matter.

We are seeking a dedicated and detail-oriented Scientist to contribute to the development of mRNA optimization workflows supporting our gene editing platforms and pre-clinical therapeutic programs. In this role, you will collaborate with cross-functional teams, including our in vivo Delivery Team, to design and implement assays that evaluate the potency and delivery of our next-generation gene editing systems. This position offers the opportunity to work at the forefront of nucleic acid-based therapies and make a tangible impact on the advancement of therapeutic solutions.  This position is located in Emeryville, California. 

 

What You’ll Do

  • Develop and optimize mRNA constructs to advance Metagenomi’s next-generation gene editing platforms. Design and implement assays to characterize the efficacy and delivery of gene editing systems.
  • Troubleshoot and resolve technical challenges related to mRNA synthesis, chemical modifications, and delivery optimization.
  • Collaborate with multiple departments to ensure successful cross-functional integration of mRNA technologies.
  • Analyze experimental data and present findings at team and company-wide meetings.
  • Prepare comprehensive data summaries and contribute to the writing of technical reports, patent applications, and scientific publications.
  • Continuously expand your scientific skills and contribute to the advancement of mRNA-based therapies.

 

What You Bring

  • PhD in biology, bioengineering, biochemistry, molecular biology, or a related discipline.
  • Minimum of 1 year of industry experience, with hands-on expertise in cloning, in vitro transcription, and nucleic acid assay development (e.g., RT-qPCR, ddPCR).
  • Proficiency in cell culture techniques, with experience in primary hepatocytes preferred.
  • Experience in the design, QC, and testing of mRNA-based therapeutics.
  • Familiarity with automated 96-well plasmid preparation and DNA/RNA purification techniques.
  • Experience with gene editing technologies, animal models.
  • Familiarity with protein detection assays using ELISA or Western blot techniques for quantification and analysis of protein expression from various biological samples. 
  • Knowledge of next-generation sequencing (NGS) analysis and proficiency with Python for scripting and data analysis.
  • Excellent oral and written communication skills with the ability to clearly present scientific data.
  • Proven ability to manage time effectively, balance multiple priorities, and work collaboratively within cross-functional teams.
  • A commitment to scientific growth and a track record of achieving results in a fast-paced research environment.

California Pay Transparency Disclosure:

Under the Federal Labor Standards Act, this position is classified as exempt. Its anticipated base salary range will be $120,000 to $150,000.  Depending on the position offered, you will also be eligible to receive equity, bonuses, and a full range of benefits. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education. 

#LI-NG1

What makes Metagenomi a unique place to work?

  • We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating diseases.
  • We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more! 
  • We offer competitive compensation, including a market-benchmarked salary, annual target bonus potential, equity, comprehensive benefits plan, 401(k) with company matching, retirement safe harbor plan, and other perks.

At Metagenomi, we know that our people drive our success. We are an equal opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. 

Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation:

Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.

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At Metagenomi, we are committed to protecting the privacy of our job applicants. The personal information you provide during the application process is collected to evaluate your suitability for employment with Metagenomi. This notice outlines how we collect, use, store, and protect your personal data.

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Your personal information is stored securely in our databases and systems. We use appropriate technical and organizational measures to protect your data against unauthorized access, loss, or misuse. Your data will be retained for as long as necessary to fulfill the purposes for which it was collected or as required by law.

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You have the following rights regarding your personal information:

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Metagenomi complies with applicable data protection laws, including the California Consumer Privacy Act (CCPA) and the General Data Protection Regulation (GDPR). We are committed to protecting your privacy and ensuring that your personal information is handled in accordance with the highest standards.

By submitting your application, you acknowledge that you have read and understood this Applicant Privacy Notice and consent to the processing of your personal data as described above.

 

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