Director, Data Platform and Orchestration

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone.  Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor.  Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”

Mineralys is a fully remote company.

Mineralys has made a deliberate architectural choice: a metadata-driven Microsoft Fabric architecture that replaces code-heavy pipelines with a configuration-driven orchestration framework — built to scale rapidly, support commercial launch, and meet the auditability standards of a regulated biotech. AI is part of how we work, and the person in this role is expected to apply it where it creates real value. 

We are looking for a Director, Data Platform and Orchestration to inherit this foundation, own it end-to-end, and evolve it into a long-term strategic asset. This is not a greenfield role — the architectural direction has been set. What we need is someone with the depth to master what has been built, the judgment to evolve it thoughtfully, and the maturity to govern a framework that is foundational to how Mineralys runs its business. 

This role demands equal parts architecture and execution — someone who can set the technical direction and then deliver against it, turning complex orchestration into data that the business can trust and act on. 

The Director will work closely with stakeholders across Commercial and R&D, lead a network of consultants and external partners, and serve as a senior voice in data governance. They will report to the VP of IT and contribute as an active member of the Digital Center of Excellence. 

This is a rare opportunity to shape how a commercial-stage biotech uses data to make decisions — with a solid foundation already in place, a business on the cusp of launch, and the mandate to take it further. 

Principal Responsibilities 

• Design and build Mineralys' data platform on Microsoft Fabric and Power BI, starting with commercial data use cases (sales performance, market access, patient analytics) and scaling progressively into R&D and broader enterprise needs. 

• Architect and implement a medallion framework (Bronze/Silver/Gold) for data ingestion, transformation, and consumption, ensuring data is reliable, traceable, and fit for purpose. 

• Identify and apply AI capabilities where they create meaningful value within the platform — accelerating pipeline development, improving data quality, or enabling smarter consumption — with the judgment to know where they don't. 

• Provide hands-on technical direction to a network of consultants and external contributors, staying actively engaged in the work — reviewing pipelines, validating data models, and making architectural calls in real time. 

• Co-own data governance frameworks alongside business stakeholders, embedding standards, definitions, and quality controls into the architecture from day one. 

• Partner with IT Infrastructure, Commercial, and R&D business units to capture requirements and validate solutions. 

• Contribute as an active member of the Technology Center of Excellence, bringing data platform expertise to broader technology strategy, and report progress, decisions, and risks clearly to the VP of IT and senior leadership. 

Skills and Attributes 

Velocity – Drive Speed with Purpose 

• Carries urgency as a mindset — because at Mineralys, the patient is waiting. 

• Anticipates what the platform needs to be, not just what it is today — thinks ahead so the business is never waiting on data infrastructure to catch up. 

• Hands-on, proven experience with Microsoft Fabric — this is a hard requirement. Familiarity with the broader Microsoft data ecosystem (Power BI, Azure Data Factory, Synapse) is a strong plus. 

• Demonstrated ability to design and implement medallion architectures (Bronze/Silver/Gold) at enterprise scale, with the discipline to deliver on time in a commercial launch environment. 

• Makes clear, confident architectural decisions under tight timelines — doesn't wait for perfect information to move forward. 

Data-Driven Decision Making – Ground Strategy in Evidence 

• Deep familiarity with how commercial organizations operate — field force deployment, market access dynamics, sales performance measurement, and patient analytics — and the ability to use that understanding to shape platform decisions that actually serve the business. 

• Experience with commercial pharma data sources (IQVIA or similar) and the ability to interpret what the data is saying — not just move it — so that what gets built is useful at the point of decision, not just technically correct. 

• Solid understanding of data governance principles and the ability to operationalize them within a platform architecture — because trustworthy data starts with disciplined design. 

• Measures success in business outcomes, not delivery milestones — tracks what matters and uses that to keep improving. 

 Agile Mindset – Embrace Iteration and Change 

• Adapts priorities as commercial and R&D needs shift, without losing architectural coherence. 

• Plans iteratively — sequences platform capabilities to match business milestones, not the other way around. 

• A self-starter who is energized by complex, evolving environments and comfortable making decisions in the absence of a complete picture. 

• Actively identifies and applies AI where it creates value in the platform Familiar with AI-enabled capabilities within Microsoft Fabric data platforms  

• Comfortable operating in a shifting AI landscape — tools, capabilities, and best practices are evolving rapidly, and adaptability is as important as current knowledge. 

Frictionless Execution – Simplify the Path to Results 

• Able to translate complex technical concepts into clear, accessible language for non-technical audiences. 

• Comfortable leading and directing external consultants and contributing partners, maintaining architectural consistency without direct authority. 

• A skilled collaborator who builds trust across IT and business stakeholders and knows how to navigate competing priorities. 

• Contributes to the Technology Center of Excellence not just as a participant but as a shaper of standards and practices. 

Autonomy – Lead with Ownership and Accountability 

• Operates with a high degree of independence — identifying what needs to be done, making the call, and driving it to completion without waiting to be directed. 

• Holds themselves and their partners accountable to delivery standards — takes ownership of outcomes, not just activities. 

• Experience supporting or delivering a pharmaceutical product launch is a significant plus — this person understands what it means to own something that truly matters. 

 

Execution that Delivers Value 

 Follows through with discipline — tracks commitments, communicates progress, and surfaces risks early rather than late. 

• Delivers results that move the business — not just technically sound work, but data that is trusted, used, and actionable by the teams that depend on it. 

• Reports progress, decisions, and risks clearly to the VP of IT and senior leadership, with the transparency a regulated biotech environment demands. 

Travel 

This position requires up to 10% travel. Frequently, travel is outside the local area and overnight. Some of the travel may be international. 

Education and Experience 

• BS/MS in Computer Science, Engineering, or a related field — or equivalent professional experience. 

• 7 to 15 years of progressive experience in data engineering, data architecture and business intelligence, with demonstrated growth in scope and complexity. 

• Hands-on, proven experience with Microsoft Fabric and Power BI — required. Familiarity with the broader Microsoft data ecosystem (Azure Data Factory, Synapse) is a plus. 

• Experience designing and implementing medallion architectures (Bronze/Silver/Gold) or equivalent data lake frameworks at enterprise scale. 

• Background in the pharmaceutical industry, with meaningful exposure to the commercial space — sales, market access, or patient analytics. 

• Familiarity with commercial pharma data sources (e.g., IQVIA, APLD, or similar) and use cases. 

•  Experience supporting or contributing to a product launch is a significant plus. 

 

This position is eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level.

US Salary Range:  $190,000 - $220,000

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