Back to jobs

Associate Director/Director of Clinical Operations (Oncology)

Cambridge, MA

About MOMA Therapeutics

 MOMA Therapeutics is a clinical-stage, next-generation precision medicine company dedicated to targeting highly dynamic proteins that underlie human disease via a small molecule approach, utilizing its proprietary KNOMATICTM platform.

The platform was designed to exploit key vulnerabilities inherent to all dynamic proteins, namely their dependence on well-coordinated, stepwise changes in protein conformation. By focusing on genetically validated targets with high translation potential, MOMA is rapidly advancing its pipeline toward responses in the clinic. MOMA's lead assets include:

  • MOMA-313 – A selective polymerase helicase theta inhibitor in Phase 1
  • MOMA-989 – A next generation selective PARP1 inhibitor currently in IND enabling studies
  • MOMA-341 – A selective Werner helicase inhibitor entering Phase 1 in 2025

MOMA’s pre-clinical pipeline consisting of wholly-owned assets and discovery partnerships with Roche and Bayer. For more information, go to www.momatx.com.

The Role:
The AD/Director, Clinical Operations (Oncology) will manage at least one oncology clinical trial under the leadership of the Head of Clinical Operations. This role will be responsible for, overseeing the design and day-to-day execution of the clinical trial, ensuring timely completion and quality data, collaborating with clinical trial centers and investigators, management of trial timelines and budget, and management of vendors and CROs. This role will have regular interaction with senior management and will be expected to communicate with and foster effective relationships with internal and external stakeholders. This is an onsite/hybrid role based in Cambridge, MA.

Key responsibilities include (but are not limited to) the following:

  • Oversee the set-up, execution, and delivery of global clinical trial projects
  • Work cross-functionally to coordinate the relevant and timeline exchange of information and materials to support clinical trial deliverables
  • Set study goals, manage timelines, and oversee vendor deliverables
  • Manage study budgets and track progress from start-up to close-out
  • Assist in authoring of clinical trial protocols, investigator’s brochures (IBs) informed consent forms (ICFs), clinical study reports (CSRs), and other clinical documents, as necessary
  • Lead protocol implementation with vendors and sites, and ensure operational feasibility of the clinical trial
  • Support the selection and management of investigators and clinical trial sites
  • Collaborate and maintain strong relationships with CROs, vendors, and sites to ensure study deliverables are met and issues/risks are proactively identified and mitigated
  • Support and manage oversight activities of all necessary vendors to ensure a high level of operational excellence is maintained
  • Collaborate with CRO and sites to ensure the clinical study database is current, accurate, and routinely cleaned
  • Support the clinical operations infrastructure build to maintain inspection readiness
  • Line management responsibilities including hiring, performance management, career development, and mentorship
  • Communicate program and trial updates, including risks and contingency plans, with senior management and key stakeholders regularly

Key qualifications include the following:

  • Bachelors degree in a scientific discipline. 
  • 8+ years of clinical research experience with at least 5 years of industry experience (pharmaceutical or biotech)
  • Minimum of 5 years of early (Phase 1-2) oncology drug development experience including experience supporting IND (CTA) submission activities. Experience in late-stage drug development is a plus.
  • Knowledge of global clinical trial management in fast paced CRO outsourced environment with the ability to assemble a plan and execute on the details
  • Excellent leadership skills and ability to lead, direct, and support cross-functional teams
  • Ability to manage multiple priorities independently in a fast-paced environment
  • Strong working knowledge of GCP/ICH and EU/EMA Guidelines for conducting clinical trials
  • Anticipated travel up to 10-20%
  • This is an onsite position in the Boston area with considerable flexibility. Candidates in the Boston area are highly preferred and are encouraged to be onsite 3+ days per week.

What We Offer:

 Our team members are empowered to deliver on their goals in a highly collaborative environment, working alongside experienced drug developers to bring highly innovative medicines to patients in need.  We offer a fast-paced, science-driven, patient-focused environment, founded on 4 core values:

    • Science with Purpose
    • Courage to Act
    • Succeeding Together
    • Joy in our Work and Each other

MOMAtes receive a highly competitive benefits package including health, dental and vision coverage as well as unlimited PTO, a week-long company wide shut down, comprehensive insurances, student loan repayment support, and family support, including family forming benefits.  We encourage all MOMAtes to work onsite 3+ days per week in an attractive lab and office environment, and provide commuting benefits, as well as subsidized lunches each day, and a range of snacks and beverages available at all times.

 Interested in learning more about how MOMA differentiates itself in the workplace? Visit the MOMA Team section of our website. https://momatx.com/team/

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Education

Select...
Select...
Select...
Select...
Select...
Select...
Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in MOMA Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.