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Clinical Director, Oncology Clinical Development

US Remote

Natera is seeking an experienced Clinical Director, Oncology Clinical Development to provide medical and scientific leadership for Natera-sponsored oncology clinical trials focused on minimal residual disease (MRD).  In this pivotal role, you’ll drive the design and execution of biomarker-driven interventional and randomized studies that integrate MRD testing into precision oncology strategies to support regulatory, scientific, and strategic objectives.

We’re looking for an innovative clinical leader with deep oncology clinical development experience who thrives in a fast-paced, collaborative environment — and who’s passionate about transforming cancer care.

Natera’s MRD platform is redefining precision oncology—enabling earlier detection, improved monitoring, and smarter treatment decisions.  In this role, you’ll lead studies that directly shape how cancer is managed worldwide, bringing actionable insights to clinicians and patients when they matter most.

What You’ll Do

Clinical & Program Leadership

  • Serve as the program-level medical lead for Natera-sponsored MRD clinical trials across assigned oncology indications, with ultimate accountability for clinical outcomes, data integrity, and patient safety.

  • Define clinical development strategies that align study design, endpoints, and execution with regulatory and scientific objectives.

  • Provide medical oversight across the full trial lifecycle, from design and protocol development through first patient in (FPI), data readout, and study close-out.

Study Design & Execution

  • Provide strategic and medical guidance to Clinical Scientists, fostering collaboration on protocol design, data interpretation, and translational insights that drive clinical program success.

  • Act as Medical Monitor, overseeing safety signal detection, adverse event review, and risk mitigation in compliance with GCP and regulatory requirements.

Cross-functional Leadership

  • Partner cross-functionally with Clinical Science, Clinical Operations, Data Management and Biostatistics to ensure timely and successful study execution, operational feasibility, and data quality.

  • Collaborate with Regulatory Affairs to support submissions, regulatory interactions, and responses, as appropriate.

Scientific & External Engagement

  • Represent Natera as the clinical development lead in interactions with investigators, key opinion leaders, IRBs, and regulatory authorities.

  • Guide interpretation of interim and final analyses, ensuring scientific accuracy and clinical relevance.

  • Provide strategic leadership for clinical study reports, and other required study-related clinical and regulatory documentation in collaboration with cross-functional partners.

  • Lead authorship and strategy for manuscripts, abstracts, and conference presentations in collaboration with Clinical Science, Biostatistics, Translational Medicine and Scientific Communications.

Organizational Excellence

  • Shape and influence the evolution of Natera’s Clinical Development organization by establishing governance standards, decision frameworks, and best practices that ensure high-quality, audit-ready execution across sponsored studies.

  • Provide senior-level mentorship and clinical leadership to Clinical Scientists, enabling consistent application of scientific rigor and regulatory standards across clinical programs.

What You’ll Bring

Required

  • MD (or equivalent)

  • ≥3 years of industry experience in oncology clinical development.

  • Demonstrated experience serving as Medical Monitor or clinical lead for Phase II–III studies.

  • Strong working knowledge of GCP, ICH guidelines, and regulatory expectations for interventional trials.

  • Proven ability to interpret and communicate complex clinical data to internal and external stakeholders.

Preferred

  • Board certification in Medical Oncology or Hematology/Oncology.

  • Experience with biomarker-driven development, molecular diagnostics, or MRD-focused programs.

  • Prior involvement in regulatory interactions (e.g., FDA meetings, briefing documents).

  • Experience working within matrixed clinical development organizations.

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

Remote USA

$221,600 - $277,000 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents. 

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
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