New

Associate Director of Real-World Evidence & Observational Research

US Remote

We are seeking an Associate Director of Real-World Evidence & Observational Research to drive the execution of real-world evidence initiatives for our early cancer detection portfolio. This role is central to generating the evidence needed to support product adoption, inform clinical use, and demonstrate value to physicians and payers.

As a seasoned clinical research professional, you will contribute to both the strategy and execution of observational research across a defined product area. You will serve as the internal subject matter expert for RWE methodologies and execution—partnering across Clinical Science, Medical Affairs, Product, and Market Access to translate key questions into actionable evidence.

This is a highly cross-functional, hands-on role requiring strong scientific judgment, operational ownership, and the ability to balance rigor, speed, and business impact.

 

 

PRIMARY RESPONSIBILITIES

Lead Real-World Evidence Strategy & Execution

  • Lead the design and execution of real-world evidence studies, including retrospective database analyses and prospective observational studies

  • Contribute to clinical evidence strategy for a defined product area, identifying where RWE can address key evidence gaps

  • Translate clinical, scientific, and business questions into robust, decision-oriented study designs

  • Proactively identify risks to study execution and implement mitigation strategies

  • Lead to protocol development, including objectives/endpoints, eligibility criteria, data collection approaches, and analysis plans

  • Partner with biostatistics and data science to ensure high-quality data analysis, interpretation, and reporting

  • Drive medical data review, interpretation, and synthesis of findings

Turn Evidence into Decisions

  • Deliver clear, actionable insights that inform product strategy, clinical positioning, and market access

  • Evaluate real-world product performance and identify opportunities to improve adoption, utilization, and outcomes

  • Partner with Product and Medical Affairs to ensure real-world insights are fed back into product development

Shape and Prioritize Evidence Generation

  • Contribute to evidence planning by identifying where RWE can most effectively address key gaps

  • Support prioritization of studies based on business impact, feasibility, and timing

  • Ensure alignment between RWE, clinical studies, and broader evidence generation efforts

Enable External Impact

  • Support development of publications, abstracts, and presentations to communicate evidence externally

  • Partner with Medical Affairs and Market Access to translate evidence into compelling narratives for clinicians, KOLs, and payers

 

Required Qualifications

  • Advanced degree (PhD, MPH, MS, PharmD, or equivalent) in epidemiology, health outcomes research, biostatistics, or related field

  • 7–10+ years of experience in real-world evidence, observational research, or HEOR, ideally in industry

  • Demonstrated experience leading the design and execution of observational studies across the full lifecycle (protocol through analysis and dissemination)

  • Strong understanding of real-world data sources (claims, EHR, registries) and their application to clinical and business questions

 

Preferred Qualifications

  • Experience in early cancer detection

  • HEOR experience

  • Experience working cross-functionally with product, medical, and commercial teams

  • Track record of translating analyses into business-relevant insights (not just publications)

 

Key Competencies

  • Strong scientific and operational judgment across the full clinical evidence lifecycle

  • Ability to independently lead complex projects with limited oversight

  • Skilled at balancing scientific rigor, speed, and resource constraints

  • Effective at influencing cross-functional stakeholders and navigating ambiguity

  • Clear and compelling communicator across technical and non-technical audiences

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

Remote USA

$146,400 - $183,000 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents. 

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
- BBB announcement on job scams 
- FBI Cyber Crime resource page 

Create a Job Alert

Interested in building your career at Natera? Get future opportunities sent straight to your email.

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Employment

Select...
Select...

Education

Select...
Select...
Select...
Select...
Select...
Select...
Select...

Natera values transparency and fair hiring practices. Disclosure of a family relationship does not automatically disqualify you from employment. This information helps us comply with our internal policies on conflicts of interest and reporting structures.

Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Natera’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.