Lead Bioinformatician/Engineer (Pipelines and Infrastructure)

Natera is seeking a Lead Bioinformatics Engineer to own pipeline and infrastructure engineering for a research informatics team working on cell-free DNA (cfDNA) screening in Women's and Organ Health. This is an individual contributor role.

You will own our WDL workflows, the transition toward Nextflow, the AWS infrastructure the team runs on, and the tooling around them. You will inherit a working system from the person who built it, and with them still on the team to teach you.

Our workflows leave clear wins available in cost and runtime for whoever takes them on. Getting scientists to the point where they process their own samples end to end, without an engineer in the loop, is a major thrust of this role.

Primary Responsibilities:

Workflow and Pipeline Engineering: Maintain and improve our WDL workflows on AWS Batch and AWS HealthOmics. Own how new Nextflow workflows and existing WDL workflows run on one set of tooling and infrastructure. Make pipelines easier for scientists to run correctly without engineering support.

Infrastructure and Operability: Own the team's AWS infrastructure, managed as code in Terraform. Improve reliability, reproducibility, and observability across our compute environments. Build testing, monitoring, and alerting that surface failures before a scientist finds them.

Tooling and Developer Productivity: Build and harden internal tooling that reduces manual work for the team, including support for triage of production issues. Make new capabilities easier to test, document, and hand off.

Ways of Working: Use coding agents as a routine part of engineering here, for implementation, code review, investigation, and operational triage. You own what you ship regardless of what produced it, which means reviewing and testing agent-written code to the same standard as your own, and helping the team decide which of these tools are worth adopting.

Collaboration and Handoff: Partner with the team's science leads and data scientists on getting new methods into production pipelines and providing first line review of their changes, and with the production organization on handoff readiness for capabilities moving out of research.

What success looks like after a year:

• You own the team's pipelines and infrastructure without supervision.
• Transition to new workflows on the same tooling and infrastructure from our existing workflows.
• Scientists run and debug their own pipeline work without coming to you first.
• Operational interruptions to the team's scientific work are down.
• Agent-assisted work is a normal part of how you work.

Qualifications:

• Degree in Bioinformatics, Computer Science, Computational Biology, or a related field. A degree is not a requirement: equivalent depth built through work counts fully.
• 4+ years of software or pipeline engineering experience, preferably in a life sciences, sequencing, or production-adjacent setting. We count relevant experience from the point your work became substantially independent, however you got there.
• Demonstrated ownership of a system end to end. We mean operating it in production, not only building the first version.

Knowledge, Skills, and Abilities:

What we are screening for

• Strong Python and software engineering fundamentals, including testing and debugging practice.
• Experience with at least one workflow system: Snakemake, CWL, WDL, Nextflow, or similar.
• Real cloud experience, ideally AWS, including managing infrastructure as code. Terraform is what we use; another tool is fine.
• Solid Linux, container, and version control practice.
• You have built at least one AI-assisted workflow you still use, and you can say what it replaced and how you know it works.
• A track record of picking up unfamiliar tools quickly, more than any specific tool on your resume.
• Clear written communication, including documentation someone else can act on.

Strong candidates may also have

• Direct WDL or Nextflow experience.
• Familiarity with AWS Batch or HealthOmics.
• Enough scientific curiosity to understand the biology behind the pipeline and ask useful questions about it.

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents. 

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
- BBB announcement on job scams 
- FBI Cyber Crime resource page