About NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position

NewLimit is seeking an scientist with experience in endothelial biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases.

Your role will focus on developing and deploying assays to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our technology teams to help create the first reprogramming medicines for the vascular tissue that supports all others.

What you'll do

In your role as a Scientist, you will:

• Develop functional assays and pre-clinical models to measure endothelial cell function
• Collaborate with our Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale
• Measure the impact of mRNA reprogramming medicines on endothelial cell function
• Engineer in vivo nucleic acid delivery methods for endothelial cells
• Analyze and interpret experimental data to drive pre-clinical decision making

Requirements

• Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
• Experience with primary endothelial cell isolation and functional characterization
• Experience working with mouse models of endothelial cell function (e.g. kidney, cardiovascular, or cognitive disease models)
• Experience with transgenic manipulation of endothelial cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)

Nice to have

• History of contributing to a drug development program at the pre-clinical or clinical development stage
• Experience leading the design and execution of pre-clinical studies in mouse models
• Experience with single cell genomics methods
• Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)