Senior/Principal Scientist, Target Identification & Validation

Nilo Therapeutics is an early-stage biotech company developing groundbreaking therapies for autoimmune and inflammatory diseases. Our experienced team brings together diverse interdisciplinary expertise to modulate immune responses via activation of neural circuits. United by our passion for discovering and translating novel biology, we are dedicated to advancing human health through transformative science.

We are backed by The Column Group, Lux, and DCVC Bio. 

Position

We are seeking a highly motivated Senior/Principal Scientist to join our Target ID & Validation team. The Senior/Principal Scientist will play a critical role in the design, development, and execution of in vitro and in vivo assays to drive our discovery pipeline. This position requires deep hands-on experience in assay development and screening within a pharma or large biotech environment, with a strong grounding in pharmacology and pharmacokinetics (PK).

Ideal candidates will use their scientific acumen and collaborative approach to partner across the interdisciplinary Nilo team on all aspects of the drug discovery process. This is an exciting opportunity to join innovative research projects and make significant contributions to our mission of advancing therapeutic solutions. 

At Nilo Therapeutics, we are a dynamic start-up at the forefront of biotech innovation, driven to discover novel biology and develop new drugs. We seek team members who are inspired by our mission and thrive in a collaborative, rigorous, and entrepreneurial environment. Ideal candidates are self-motivated, proactive problem solvers, excited to build and grow the company alongside a world-class team. If you are comfortable with managing multiple projects and possess a resourceful, can-do attitude, we would love to hear from you. Join us and contribute to our mission of advancing innovative therapies at the intersection of neuroscience and immunology.

What you’ll do:

• Lead the design, development, and optimization of in vitro and in vivo assays to evaluate drug candidates.
• Drive screening efforts in collaboration with cross-functional project teams.
• Interpret pharmacology and PK data to guide compound progression.
• Contribute to hit-to-lead and lead optimization campaigns with a focus on translational relevance.
• Work closely with medicinal chemistry, biology, and pharmacology colleagues to refine experimental strategies.
• Mentor junior scientists and bring a pragmatic, experience-first approach to problem-solving.

Key Qualifications:

• Pharma/large biotech experience with a track record in small molecule screening and drug discovery
• Proven expertise in assay development and optimization
• Hands-on in vivo and in vitro experience
• Strong working knowledge of pharmacology and PK principles
• Experience in working on neuronal targets is highly desirable
• Degree in pharmacology, biology, or related discipline. Practical experience is valued over credentials.
• Proven ability to work collaboratively in a multidisciplinary team environment and motivated to make significant contributions for the growth of a high-paced start-up
• A passion for high-quality, translational science and a desire to discover novel biology and new drugs

We offer a competitive compensation package that includes a range of benefits designed to support the well-being and professional growth of our team members. Leveling and compensation will be commensurate with experience.

For consideration, please share your cover letter and resume with our hiring team.

Nilo Therapeutics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment. We are committed to creating a diverse and inclusive environment and encourage individuals from all backgrounds to apply