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Director, Medicinal Chemistry

Boston, MA

At Nimbus Therapeutics, we leverage our world-class discovery engine by combining computational chemists, structure-based drug design expertise (SBDD), and experienced medicinal chemists with diverse therapeutic area biologists and development teams. Focused on immunology/inflammation, oncology, and metabolic diseases, we are a nimble biotech company with a proven track record of success. Our mission is to discover innovative medicines for highly validated targets using cutting-edge tools.

Reporting to the Vice President of Medicinal Chemistry, this individual will play a pivotal role in advancing multiple small molecule drug discovery campaigns and will combine scientific decision-making with organizational leadership to drive projects from hit identification to development candidate.

In This Role, You Will:

  • Lead multidisciplinary drug discovery chemistry teams in a fast-paced, results-driven biotech environment
  • Design, implement and execute robust medicinal chemistry strategies to meet project objectives
  • Establish and maintain partnerships to leverage external expertise and resources
  • Collaborate effectively various departments, functions, and leadership team members to align on project goals and strategies
  • Plan and allocate resources effectively to optimize project outcomes
  • Provide strategic, scientific and managerial guidance within an outsourced medicinal and synthetic chemistry framework
  • Contribute to the overall scientific direction and success of the organization's current and future pipeline

These Qualifications Will Help This Role Be Successful:

  • Ph.D. or equivalent  in Synthetic Organic Chemistry, Medicinal Chemistry, or a related field
  • 10+ years of drug discovery experience within the biopharmaceutical industry, including a demonstrated strong track record of scientific innovation and success in delivering clinical candidates
  • In-depth understanding of drug discovery processes, including ADME/PK, pharmacology, physicochemical property optimization, computational chemistry, and safety/toxicology considerations
  • Established record of success in application of structure-based drug design to clinical candidates
  • Experienced leading multidisciplinary drug discovery teams with experience in hit identification to development candidate and beyond
  • Significant experience managing synthetic chemistry activities with CROs in Asia and/or Eastern Europe
  • Strong organizational, interpersonal, communication, and managerial skills with the ability to motivate and inspire teams to achieve scientific objectives

A Snapshot of Nimbus 

Our Science  

At Nimbus, we design breakthrough medicines. Utilizing our powerful structure-based drug discovery engine, we create potent and selective small molecule compounds targeting proteins that are known to be fundamental drivers of pathology in highly prevalent human diseases and which have proven difficult for other drug makers to tackle. With a decade-plus track record of success, we’ve built a world-class team in both computationally driven drug discovery and early clinical development while continuing to move the needle for patients.  

Our Culture 

Nimbus is a close-knit company (our employees are Nimbi, if you are curious!) that values a fast-paced, entrepreneurial, intellectual-stimulating, and collaborative environment. We live by our Core Values: Integrity, a Passion for Excellence, Teamwork, and Authentic Communication and strive to build a community where we bring out the best in each other professionally and personally.  

Our Company 

Founded in 2009, Nimbus is a private, growing biotechnology company headquartered in Boston, Massachusetts. Learn more about us by going to www.nimbustx.com 

Join Nimbus. We are making a difference and you can too. 

At Nimbus, we believe our diversity of backgrounds and experiences strengthens our community and our ability to design breakthrough medicines. We prioritize creating an inclusive, welcoming culture that promotes our core values and encourages every Nimbi to bring their whole selves to their work. Nimbus is proud to be an equal opportunity employer. We value and celebrate all our employees and recognize that our diversity and inclusion are keys to our success. Nimbus is committed to providing equal opportunity for all employees and applicants without regard to race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Nimbus does not accept unsolicited resumes from any source other than directly from candidates.

 

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