Back to jobs

Therapeutics Architect

San Francisco or New York

WHY NOETIK

NOETIK is a frontier therapeutics company harnessing AI to deeply understand human biology and redefine clinical outcomes in oncology. Leveraging the largest proprietary multimodal oncology dataset of its kind, uniquely integrating deep spatial profiling with routine clinical assays, NOETIK’s foundation AI models precisely match therapeutic targets to patient subpopulations and accurately predict clinical efficacy. This AI-first approach elevates therapeutic development from probabilistic guesswork to precision science.

THE REMIT OF THE BIOLOGIST IS CHANGING 

Drug discovery and development is a decision-making problem. We are generating more data and building better models, but real impact comes from knowing which questions matter and what evidence actually impacts a program’s trajectory. We need scientists who can pair model-driven outputs with sharp therapeutic judgment to figure out which therapies should exist, and for whom.

Ultimately the gig is translating those outputs into defensible portfolio calls. This means being deep in biology and therapeutic concepts, while also being genuinely engaged with frontier AI and how that is changing how we work. You will be the architect of new and better systems for discovering and developing drugs.

THE OPPORTUNITY

You'll join a cross-functional therapeutics team responsible for surfacing promising therapeutic opportunities, pressure-testing their scientific and translational logic, and shaping how programs move through the pipeline. We're intentionally building a different kind of therapeutics group to support this work, because turning human foundation models / insights into new therapeutic concepts and real patient impact requires a fundamentally different way of working.

As such, the people who will thrive here are also fundamentally different. They bring an AI-native perspective, incorporating agentic tools and machine intelligence alongside their own domain expertise to reason through problems. They're platform-first, always asking what an AI-native platform can see that nobody else can, and what that’s worth for therapeutic decisions. They're a drug hunter that knows the difference between an interesting hypothesis and a viable therapeutic concept that can become a real molecule that reaches real patients. And they're portfolio-oriented, optimizing for the company's best collective shots and making principled decisions about where the greatest therapeutic opportunity lies.

This role is hybrid, and can be located in either our South San Francisco office, or be based remotely in New York.

Key Responsibilities:

  • Own the evaluation and championing of biological insights and therapeutic opportunities from first look through portfolio nomination.
  • Work cross-functionally to drive programs forward by defining the questions, decision criteria, and actions required at each stage
  • Develop platform-informed hypotheses around therapeutic targets, mechanisms, patient populations, biomarkers, and clinical strategy
  • Build evidence packages that inform investment, partnering, and development decisions
  • Design and improve AI-enabled scientific workflows that increase the durability and quality of therapeutic decision-making
  • Prioritize across the portfolio by balancing biological opportunity, technical feasibility, clinical impact, and strategic fit

WHAT WE’RE LOOKING FOR

The strongest candidates embrace uncertainty and treat new technology as a candidate baseline for scientific reasoning the moment it emerges. Curiosity drives them across disciplines, where they direct intelligent systems to explore ideas, challenge assumptions, and surface hypotheses they wouldn't have found alone. But just as importantly, they bring judgment back. Meaning they can separate plausible outputs from meaningful outputs, recognize weak or circular reasoning, and can combine machine intelligence with deep biological and therapeutic discernment to make better decisions. And finally, they are company and portfolio builders rather than single-project owners. They hold strong scientific opinions, adapt when the evidence changes, and optimize for the company’s best path forward for success.

Qualifications:

  • PhD, MD, or equivalent experience in cancer biology, immunology, pharmacology, molecular biology, translational medicine, or a related discipline
  • Bona fide experience on drug discovery or development programs, with a working feel for the scientific, operational, and strategic go/no-go decisions required to move a program forward… or kill it
  • Strong intuition for turning hypotheses into viable therapeutic programs, spanning target validation and modality considerations through translational strategy and positioning
  • Genuine comfort in a room that mixes biology, machine learning, computational science, and strategy, where no one person holds the singular answer
  • Hands-on use of modern AI tools in scientific work, with examples of how they’ve changed the way you investigate questions, evaluate evidence, or make therapeutic decisions
  • A systems-thinking mindset with the ability to prioritize across competing scientific opportunities
  • Excellent scientific judgment, clear communication skills, and the ability to influence across diverse stakeholders
  • Bonus: experience with computational biology, data science, machine learning, or programming (Python, R, SQL), though deep biological reasoning and therapeutic judgment are more important than any particular technical stack

 

Life@Noetik

Great science is a team sport. We are focused on creating a culture where brilliant people from different backgrounds can solve hard problems together. At Noetik, culture isn't just about perks; it’s about building a vibrant, collaborative community where everyone has the tools and the autonomy to thrive.

How We Work

Location & Collaboration: our primary lab and office space is located in South San Francisco. We operate as a hybrid organization, utilizing Slack, Zoom, and a modern tech stack to stay seamlessly connected regardless of time zone.

Intentional Connection: we believe that high-impact work requires intentional time together. We keep the team aligned through monthly All-Hands meetings and Quarterly Co-working Weeks at our South San Francisco office. Once a year, we gather for an Annual Reset - a week-long offsite dedicated to high-level strategy, collaboration and team bonding. Past locations have included Austin, TX, Park City, UT, and Boulder, CO.

Onsite Community: For team members working onsite, we foster a collaborative environment and refuel with daily catered lunches from great local restaurants and Boba Thursday - a small but meaningful tradition where we step away from our desks to connect over a break.

How We Support You

Health & Wellbeing: we provide generous health, dental, and vision insurance, with premiums fully covered for both employees and their dependents (depending on your plan choice). Our coverage is designed to be comprehensive and accessible, featuring modern care platforms like OneMedical, Midi Health, Spring Health, and XP Health. To further support your needs, we offer HSA and FSA accounts, dependent care savings, an EAP, resources for mental health (Rula), and health care navigation and advocacy (Rightway).

Time Off & Synchronized Breaks: we offer Flexible PTO to manage your personal time, alongside nine paid holidays. We also offer synchronized breaks so that the team can fully unplug simultaneously -  two full-week company breaks (the first week of July and the last week of December), plus the Friday after Thanksgiving.

Compensation & Financial Benefits: our financial package includes a competitive base salary, stock options, and a 401(k) plan with an employer match. We provide a safety net through fully-covered disability, life and AD&D insurance, as well as generous parental leave. We also offer a suite of financial and lifestyle tools, including SoFi, Multiply Mortgage, and optional programs for pet insurance, legal services, and identity theft protection.

We believe that the highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other.  We are committed to an open, diverse and inclusive culture for all employees. Noetik is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status and any other characteristics protected under applicable federal, state and local laws.

Apply for this job

*

indicates a required field

Resume/CV

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Education

Select...
Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Noetik’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 07/31/2029

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.