Director, Enterprise Applications

Brisbane, CA

Position Summary

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

This role owns the business systems that support Nurix's path from clinical trials through commercialization. You will be the primary IT partner to Clinical Operations, Regulatory, Quality, and Commercial leadership, ensuring the technology they depend on works and evolves with the business. 

The scope includes clinical systems (EDC, eTMF, pharmacovigilance, regulatory submissions), quality and training platforms, and commercial systems as they come online. You manage vendor relationships for delivery outcomes, work with Quality on validation requirements, and coordinate with IT Strategy & Vendor Operations on contracts and shared infrastructure. 

This is a strategic role with hands-on expectations. You will define requirements, design workflows, run implementations, and ensure adoption. If a vendor falls short or a gap emerges, you can configure, troubleshoot, or build what's needed. You're not above the work. 

The goal is to function as a mini-CIO for the life sciences enterprise application portfolio. Over time, the role grows with the company. As Nurix advances toward commercial stage, you will shape the systems strategy and build a team to support it. 

Primary Responsibilities 

Business partnership 

  • Serve as primary IT partner to Clinical Operations, Regulatory, Quality, and Commercial 
  • Translate business needs into system requirements and implementation plans 
  • Own stakeholder satisfaction for the enterprise applications portfolio 
  • Proactively identify technology opportunities that enable business outcomes 

Application portfolio management 

  • Own the clinical, quality, regulatory, and commercial application portfolio 
  • Current systems: Medidata Rave (EDC), Wingspan eTMF, Argus (pharmacovigilance), Veeva Vault RIM (submissions), Veeva CRM, Veeva QMS, VeevaDocs, Veeva Training 
  • ERP/back-office systems as commercial operations expand 
  • Define application roadmap aligned to clinical milestones and commercial readiness 
  • Manage system integrations, data flows, and reporting needs 

Implementation and delivery 

  • Lead implementations end-to-end: requirements, configuration, testing, training, go-live 
  • Coordinate with clinical PM contractor on project execution 
  • Align with IT Project Manager on resource conflicts, shared vendors, and portfolio reporting 
  • Manage UAT coordination, training development, and change management 

Vendor management 

  • Own functional relationships with application vendors (what gets built, does it work, is it adopted) 
  • Partner with Director, IT Strategy & Vendor Operations on contracts, SOWs, and vendor governance 
  • Hold vendors accountable for delivery outcomes and service quality 
  • Ensure vendors build internal capability, not dependency 

Compliance and quality 

  • Partner with Quality on GxP validation requirements for regulated systems 
  • Understand CSV principles; work alongside Qualitas and internal validation resources 
  • Support FDA inspection readiness for IT-related controls 
  • Ensure 21 CFR Part 11 compliance for electronic records and signatures Organization 

Required Qualifications 

  • 10+ years in IT, with 5+ years in life sciences or pharmaceutical environments 
  • Direct experience with clinical systems: EDC, eTMF, CTMS, safety/PV, or regulatory submissions 
  • Veeva platform experience (Vault, CRM, QMS) 
  • Medidata Rave experience 
  • Track record leading application implementations from requirements through adoption 
  • Experience managing vendors for delivery outcomes (not just contract administration) 
  • Working knowledge of GxP validation principles and 21 CFR Part 11 
  • Strong business analyst skills: requirements gathering, process design, stakeholder facilitation 
  • Comfortable with hands-on configuration and troubleshooting when needed 
  • Effective communicator with scientific, clinical, and business audiences 
  • Bachelor's degree in a technical field, or equivalent experience 

Strongly Preferred Qualifications: 

  • Experience supporting regulatory submissions or FDA inspection readiness 
  • Commercial systems experience (CRM, market access, patient services) 
  • ERP implementation or administration experience 

Organization 

Reports to:  SVP IT 

Key partners: 

  • Director, IT Operations (contracts, vendor governance, shared infrastructure) 
  • IT Project Manager (portfolio coordination, resource alignment) 
  • Clinical PM contractor (implementation project execution) 
  • Sr. Director and CISO (security, compliance) 
  • USDM (system validation, GxP compliance) 

Primary stakeholders: 

  • Clinical Operations leadership 
  • Regulatory Affairs leadership 
  • Quality leadership 
  • Commercial leadership 

Salary Range: $216,000 to $251,000 Plus Bonus and Equity

Location: Brisbane, CA - Onsite 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

 

Create a Job Alert

Interested in building your career at Nurix? Get future opportunities sent straight to your email.

Apply for this job

*

indicates a required field

Resume/CV

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Nurix’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.