New

Senior Vice President, Preclinical Toxicology

Brisbane, California

Senior Vice President, Preclinical Toxicology

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

The Senior Vice President, Toxicology (Safety Pharmacology) leads Nurix's nonclinical safety function and reports to the Chief Scientific Officer. This role sets toxicology and safety pharmacology strategy across the portfolio, from discovery through clinical development, and represents Toxicology to senior management, the Board, external partners, and regulatory authorities.

The SVP operates across three dimensions: leading an internal team and managing the department's CRO relationships, budget, and study portfolio; setting strategic direction for nonclinical safety across programs and the portfolio; and executing with the scientific rigor and credibility to influence program-level decisions and Nurix's broader R&D direction.

Responsibilities

  • Set toxicology and safety pharmacology strategy across the discovery, preclinical, and clinical portfolio, and make sure nonclinical safety plans align with the company's development priorities and risk tolerance.
  • Represent Toxicology on the Research & Early Discovery leadership team and be a key contributor to portfolio prioritization, program governance, and related decisions.
  • Lead and develop an internal Toxicology team, including hiring, mentoring, and setting priorities as workload and the portfolio evolve.
  • Direct the design and execution of preclinical pharmacology, pharmacokinetic, mammalian toxicology, and genetic toxicology IND-enabling studies (GLP and non-GLP), ensuring packages meet regulatory filing standards.
  • Manage the Toxicology department budget and resourcing, including decisions about what stays in-house versus what goes to CRO partners.
  • Select and oversee the CRO and external partner network, including contracting, risk management, and quality oversight of outsourced GLP and non-GLP studies.
  • Serve as the senior toxicology representative in interactions with FDA and other health authorities, including IND, CTA, NDA, BLA, and MAA submissions and agency meetings.
  • Communicate toxicology findings and risk assessments clearly to program teams, senior management, and the Board, translating nonclinical safety data into practical implications for decision-making.
  • Provide toxicology and safety input on business development activities, including due diligence on in-licensing or partnership opportunities.
  • Resolve nonclinical safety issues that develop across discovery and development programs, and assess the relevance of toxicological findings to human risk.
  • Represent Nurix Toxicology externally, including with key opinion leaders, industry groups, and regulatory forums.

Required Qualifications

  • D., M.D., or D.V.M. in Toxicology, Pharmacology, or a related discipline.
  • Minimum 15 years of drug development experience in the pharmaceutical or biotechnology industry, including experience leading a toxicology or nonclinical safety functionTrack record advancing multiple programs from IND through Phase I, II, and III clinical development, with direct experience authoring and defending FDA and international regulatory submissions.
  • Experience with ADCs (Antibody-Drug Conjugate) and small molecule strongly preferred
  • Experience presenting toxicology and nonclinical safety strategy to senior management and external stakeholders, including investors and partners.
  • People-leadership experience, including hiring, developing, and managing a team, plus experience owning a department budget.
  • Strong knowledge of safety pharmacology and toxicology study design in compliance with GLP, ICH, FDA, and EMA guidelines across multiple therapeutic modalities.
  • Proven experience preparing and defending regulatory submissions (IND, CTA, NDA, BLA, MAA, etc.) in direct interactions with global regulatory authorities.
  • Experience contributing a toxicology and safety perspective to business development or due diligence activities preferred.
  • Strong communication skills, with the ability to influence senior leadership and represent the function credibly outside the company.
  • Certification by the American Board of Toxicology (D.A.B.T.) required or strongly preferred.
  • Travel required as needed.

Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Salary Range: $360K – $420K

Location: Brisbane, CA (Onsite role)

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).

 

 

Create a Job Alert

Interested in building your career at Nurix? Get future opportunities sent straight to your email.

Apply for this job

*

indicates a required field

Resume/CV

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Nurix’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.