Senior Director, Business Applications

Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist (CERAN) currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with best-in-class potential.  

Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another. At Olema, we know that when we put people first, our work becomes second to none. If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for our patients, for your career, for what’s beyond. 

You can view our latest corporate deck and other presentations here.

About the Role >>> Senior Director, Business Applications 

As the Senior Director, Business Applications reporting to the Vice President, Information Technology, you are a seasoned and visionary Senior Director who will oversee and optimize all General & Administrative (G&A) business systems. You will lead a high-impact team in enhancing, hardening, and scaling enterprise systems to support Olema’s transition toward commercialization and sustained growth. This is a unique opportunity to make a meaningful impact at a dynamic biotech company during a pivotal phase in its development.  

This role is based in either our San Francisco or Boston office and will require 10% travel. 

Your work will primarily encompass: 

• Own the strategic roadmap, budget and day-to-day management of G&A business systems including NetSuite, Prendio, Agiloft, BambooHR, Greenhouse, and Culture Amp
• Hardening existing systems to prepare for commercialization and ensure enterprise scalability, audit readiness, and compliance with SOX (404A & B) requirements
• Partner with Finance, HR, Legal, Procurement, Talent, Facilities and IT teams to understand evolving business requirements and deliver efficient, scalable solutions
• Ensure successful adoption of new technologies and enhancements through structured change management practices, including communication, training, and stakeholder alignment
• Evaluate and implement AI-driven tools and automation platforms, and workflow optimization solutions – such as Workato or similar iPaas technologies - to improve business performance and operational efficiency
• Drive continuous improvement and digital transformation efforts by identifying opportunities for process redesign, automation and integration across systems
• Ensure application governance, data integrity, system security, and adherence to internal controls and SOX processes
• Lead system and vendor evaluations, platform assessments, and RFP processes to achieve the optimal technical fit and value for the organization
• Manage vendor relationships and contract negotiations for SaaS platforms and service providers
• Provide oversight and partnership with R&D teams (~10–15% of your time) to support scientific applications, data workflows, and system integrations that enable research innovation
• Mentor and grow a high-performing Business Applications team aligned with Olema’s culture and mission

Ideal Candidate Profile >>>  

A love of challenging, important work. We are a pragmatic team, driven to imagine and develop meaningful therapies for improving lives. All employees within our company play a unique and crucial role in our success, both in accomplishing our mission and building a positive company culture. As such, we are looking for someone with the right combination of knowledge, experience, and attributes for this role. 

Knowledge: 

• Bachelor's degree in information systems, computer science, or related discipline; advanced degree preferred
• Strong knowledge of AI technologies, data management, and automation tools to drive digital transformation
• Demonstrated leadership in managing cross-functional teams and complex system implementations
• Proven success scaling and hardening systems in preparation for commercialization
• Demonstrated ability to translate business requirements into technical solutions and architect scalable, future-ready systems

Experience: 

• A minimum of 10+ years of experience managing enterprise applications, with a strong background in G&A systems within the biotech or pharmaceutical industry
• A minimum of 5+ years of experience building, leading, managing, developing and mentoring direct reports
• Hands-on experience with NetSuite is a must. Prendio, Agiloft, BambooHR, Greenhouse, and Culture Amp, Workato or similar tools highly preferred
• Track record of process optimization, workflow automation, and driving operational efficiency
• Experience working within or preparing organizations for SOX compliance, including system controls, audit requirements, and governance
• Proven success in system and vendor selection, including leading evaluations, RFPs, and contract negotiations

Attributes: 

• Exceptional communication skills and the ability to influence stakeholders at all levels of the organization
• Strong commitment to excellence and delivering outstanding user experiences
• Highly analytical and data-driven decision-maker
• Proactive, self-motivated, and results-oriented with a "bias for action" 
• Collaborative team player who thrives in a cross-functional environment
• Flexible and adaptable to evolving business needs and technology trends

The base pay range for this position is expected to be $270,000 - $290,000 annually; however, the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits. 

#LI-MT1

Important Information >>>

We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated.

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants.

Please note: Olema doesn’t accept agency resumes and is not responsible for any fees related to unsolicited resumes. Thank you.

Fraud Alert:  We are aware of employment scams where individuals pose as representatives of Olema Oncology and make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olema.com; our careers page is olema.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology. Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in-person interview.