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NGS Scientist/Sr Scientist
Orna Therapeutics is seeking a highly skilled and motivated NGS Scientist or Senior Scientist to join our innovative research team. The ideal candidate will possess strong technical expertise in next-generation sequencing (NGS) technologies, with a focus on protocol development, optimization, and troubleshooting. This role requires hands-on experience with NGS platforms, a deep understanding of molecular biology, strong organizational skills, and a collaborative spirit to work closely with cross-functional teams and external partners.
Key Responsibilities:
- Technical Expertise: Execute NGS-based experiments, including sample preparation, library construction, sequencing, and initial data quality assessment, to support ongoing research projects.
- NGS Protocol Development: Maintain, develop, and optimize NGS protocols, including library preparation, sequencing, and quality control, to support various research and development projects.
- Sample Preparation: Perform and oversee the preparation of samples for NGS, including animal tissue and cell extraction techniques. Ensure samples are of high quality and suitable for sequencing.
- Collaboration: Work closely with research scientists, bioinformaticians, and other collaborators to design experiments and ensure seamless integration of NGS workflows into broader research objectives.
- Troubleshooting: Identify and resolve technical challenges related to NGS workflows, including issues with instrumentation, reagents, and sample quality.
- Training & Support: Provide training and technical support to junior scientists, lab technicians, and collaborators on NGS protocols and instrumentation.
- Documentation: Maintain comprehensive records of experimental procedures, optimizations, and outcomes. Contribute to technical reports and publications as needed.
Qualifications:
- Ph.D. in Genomics, Molecular Biology, Biotechnology, or a related field with 2+ years of relevant experience; or equivalent qualifications
Experience:
- Extensive hands-on experience developing and executing NGS-based experiments, especially amplicon-based workflows.
- Intimate familiarity with Illumina-based protocols, instruments, and reagents. Experience with Oxford Nanopore is a plus.
- Proven ability to develop, optimize, and troubleshoot NGS protocols, from sample preparation to sequencing.
- Knowledge of and experience with animal tissue handling, cell & tissue culture techniques.
- Experience with automation and high-throughput sequencing workflows is also desirable.
Skills:
- Deep understanding of molecular biology techniques and their application to NGS.
- Strong technical proficiency with NGS instruments, including maintenance and troubleshooting.
- Demonstrated ability to work collaboratively in a team-oriented environment, fostering a positive and supportive workplace culture.
- Strong organizational skills and attention to detail, with the ability to manage multiple projects simultaneously.
- Effective communication skills, both written and verbal, with the ability to convey technical information clearly.
- Good lab notebook practices, with an emphasis on appropriate data and sample management.
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