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Sr. Bioinformatics Scientist – Novel Cell Free DNA Applications

Fremont, CA

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

The Senior Bioinformatics Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Senior Bioinformatics Scientist will work closely with our clinical evidence generation teams, applying our cell-free technology solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection.

Days onsite: Monday and Tuesday

Responsibilities:

  • Design and develop novel cell-free technologies and products
  • Collaborate closely with laboratory scientists to design experiments to develop and evaluate novel applications for cell-free DNA assays
  • Draw on deep experience with genomics and statistics to model and improve performance of cell-free assays and features
  • Synthesize large datasets to develop and evaluate new biological and technological hypotheses
  • Partner with the clinical evidence generation team to ensure the applicability and evaluate the performance of novel assays or feature improvements 
  • Maintain a strong working knowledge of literature covering technological developments in the cell-free DNA and liquid biopsy space
  • Publish results and present at conferences in exciting areas, including cell-free DNA and cancer genomics

Requirements:

  • Advanced degree (Ph.D.) in bioinformatics, genomics, or a related field
  • Extensive experience with cancer genomics 
  • Extensive experience with somatic mutational detection and filtering
  • Experience with cancer liquid biopsy analysis
  • Proficiency in the application of statistical methods to genomic applications
  • Proficiency with at least one common programming language (e.g., Python, R)
  • A track record of designing and implementing experimental approaches to confirm and elaborate upon findings from complex projects
  • Experience publishing and presenting scientific results

 

The hiring range for this position is $150,000 to $190,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

 

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

 

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