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Principal Scientist, Formulation Development

United States - Remote

Location:  This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity

We're looking for a Formulation Scientist to lead drug product development from early discovery through late-stage clinical trials. This role is key to translating promising compounds into high-quality, scalable drug products—supporting everything from preclinical formulation to manufacturing clinical supplies. You'll apply your expertise in formulation development, material characterization, and process scale-up, while also managing relationships with CDMOs to keep things moving smoothly. The ideal candidate combines strong technical skills with curiosity, ownership, and a collaborative mindset—and is excited to work across teams to help bring new therapies to patients. 

Primary Responsibilities

  • Ability to represent Formulation on CMC teams and Pharmaceutical Development in multidisciplinary project teams, work collaboratively to ensure project progression, and communicate Formulation/Pharmaceutical Development strategy and related challenges.   
  • Plan, design, and supervise the execution, and interpret laboratory experiments to properly characterize novel drug candidates (small molecules and/or ASO).   
  • Apply formulation and manufacturing principles, theories and techniques to product development and develop the best possible phase appropriate formulations and manufacturing processes.  
  • Work closely with drug discovery teams to ensure timely and high-quality support for preclinical studies.  
  • Author technical reports and CMC sections of the regulatory dossiers (INDs, IMPDs, and NDAs etc.).    
  • Manage the activities of formulation scientists at CDMOs focused on formulation and manufacturing process development. 
  • Work effectively with CDMOs by providing technical oversight to ensure that Praxis’s formulation development and clinical manufacturing needs are met.   

 

Qualifications and Key Success Factors

  • BS, MS, or PhD in pharmaceutical sciences, chemical or biochemical engineering, chemistry or related scientific field and 7+ years (12+ years for BS/MS) of industrial experience.   
  • Strong fundamental understanding of physicochemical and biopharmaceutical properties and their importance in formulation design.  
  • Strong communication, project management, and interpersonal skills.   
  • Effective and innovative problem-solving skills along with the ability to bring together colleagues across functions. 
  • Demonstrates voracious intellectual curiosity, innovation and creative problem solving with an entrepreneurial spirit; can thrive in an agile environment. 
  • Ability to think critically with a keen sense of urgency and demonstrated problem solving abilities. 
  • Self-motivated, able to influence and guide the work of other team members, and contribute to a productive and collaborative team environment.0 
  • Highly organized and detail-oriented with a passion to deliver quality results 
  • Comfortable with independently making decisions and communicating in a direct fashion.  
  • Approaches his/her work with high levels of professionalism, integrity, and personal confidence.    

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together! 

To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below.  Final salary range may be modified commensurate with job level, education, and experience.

Annualized Base Salary

$155,000 - $176,500 USD

Company Overview 

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance.  At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.  Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

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