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Senior/Associate Scientist, In Vivo

Cambridge, MA

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.

Position Overview

We seek a self-motivated and technically proficient in vivo scientist to join our team here at Prime Medicine. The candidate will support our Research using gene editing in multiple disease areas, including Hematology & Immunology, Liver, CNS and ocular programs. Their work will directly contribute to the development of in vivo gene editing therapies, making a significant impact in the field.

Primary Responsibilities:

  • Design, plan, and execute in vivo studies
  • Perform different routes of administration (SC, IP, IV, PO, ICV) in mice, monitor animal health, and harvest samples from multiple tissues
  • Support the implementation and validation of new animal models
  • Perform DNA and RNA extraction from multiple tissues
  • Perform in vitro assays such as ELISA, ELISpot, Luminex, flow cytometry, and qPCR
  • Working knowledge of cell culture in primary cells and cell lines
  • Analyze data using software including FlowJo, Excel, and GraphPad Prism
  • Follow IACUC protocols and standard operating procedures (SOPs)
  • Coordinate in vivo pharmacology research in a matrixed environment, as well as external academic collaborations and an extensive network of CROs

Qualifications:

  • BA/BS or MS with at least five years of experience in the biotechnology or pharmaceutical industry
  • Experience with necropsy procedures is essential
  • Expertise with rodent handling and different routes of administration (IV, IP, SC, ICV, and IM)
  • Expertise with working in hematology and/or immunology animal models preferred
  • Experience with ELISA, flow cytometry, qPCR, and other plate-based assays preferred
  • Working knowledge of cell culture and sterile techniques
  • Experience in maintaining an electronic, laboratory notebook and following protocols
  • Familiarity with programs such as Excel, GraphPad Prism, FlowJo, and PowerPoint for data entry and analysis
  • Desire and drive to learn and understand the basic biologic mechanisms of Prime Editing technology
  • Team player with excellent oral and written communication skills and a “do-what-it-takes” attitude
  • Independently motivated, detail-oriented, and excellent problem-solving abilities
  • Excellent organizational skills in multi-tasking in a highly fast-paced environment with rapidly changing priorities

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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