Spring 2025 Co-op: Analytical Development

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.

Co-op Assignment Overview

Prime Medicine is seeking a diligent, motivated, and enthusiastic co-op for the Spring 2025 cycle who has experience and interest in analytical technologies including HPLC and capillary electrophoresis to join the analytical development (AD) team. The successful candidate will be able to participate in the development of separation-based methods for Prime Editor delivery platform and work cross-functionally to advance the Prime pipeline. There will be also many valuable opportunities to participate in other projects that are crucial to the success of in vivo and ex vivo gene editing therapeutic drug development.

Primary Responsibilities:

• Perform a variety of assays to support companywide analytical needs for the analysis of therapeutic biomolecules, e.g., lipid nanoparticle (LNP), and adeno-associated virus (AAV) drug products and their components.
• Assist in developing ideas for new methods or experiments, and implementing new techniques.
• Separation-based method development to assess AAV/LNP characterization.
• Biophysical measurement of AAV/LNP drug products.
• Provide analytical support for cell therapy development as needed.
• Data analysis, interpretation, and presentation within the team.

Qualifications:

• B.S. or M.S. candidate in biochemistry, chemistry, chemical engineering, or a related field.
• Basic knowledge of separation sciences and technologies.
• Ability to handle multiple projects in a fast-paced environment.
• Excellent troubleshooting and communication skills.
• Ability to work independently and within a team.
• Skilled in documenting findings and activities in comprehensive reports and ensuring proper inventory of materials and analytical equipment.

Preferred Qualifications:

• Hands-on experience with LC-MS and capillary electrophoresis is preferred.
• Understanding of flow cytometry principles.
• Experience with biophysical techniques (e.g., DLS) is preferred.
• Previous co-op experience in biotechnology industry.
• Independently motivated, detail-oriented, and excellent problem-solving abilities.

What We Offer:

• A cutting-edge team open to mentorship and networking.
• Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
• Participation in regular seminars with industry experts.
• Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.