Spring 2025 Co-op: Hematology & Immunology

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.

Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Spring 2025 cycle with knowledge in cell and molecular biology to join the Hematology and Immunology team. The qualified candidate will work hands-on with a highly collaborative, fast-paced project team to validate promising Prime Editors for hematological indications. In this position, you will learn and perfect cell and molecular biology skills and develop a deep understanding of gene editing and hematopoietic stem cell and T cell biology. Primary

Responsibilities:

• Aseptic culture of primary human T cells and hematopoietic cells
• Preparing primary immune and hematopoietic stem cell samples for flow cytometry assays
• Preparing protein samples from Prime Edited primary human hematopoietic cells and running Western blots
• Processing samples for genomic DNA isolation and subsequent DNA sequencing analysis (extraction, PCR, MiSeq preprocessing)
• Data analysis, interpretation, and presentations within the team

Qualifications:

• B.S. candidate in Cell & Molecular Biology or related discipline
• Basic knowledge of molecular biology, cell biology and biochemistry
• Excellent troubleshooting and communication skills
• Ability to work independently and within a team

Preferred Qualifications:

• Hands-on experience with aseptic cell culture of mammalian cells
• Experience with basic molecular biology assays (Western blot, DNA extraction, PCR etc.)
• Experience with flow cytometry
• Familiarity with Excel and PowerPoint for data analysis
• Independently motivated, detail-oriented, and excellent problem-solving abilities

What We Offer:

• A cutting-edge team open to mentorship and networking.
• Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
• Participation in regular seminars with industry experts.
• Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.