Back to jobs

Senior Manager, R&D Informatics

Cambridge, MA

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.

Position Overview:
Prime Medicine is seeking a Senior Manager, R&D Informatics to lead and enhance our research data systems, ensuring seamless digital infrastructure and data management to support cutting-edge gene editing research. This role is pivotal in integrating advanced informatics platforms, optimizing workflows, and driving digital transformation across R&D.

This position will combine hands-on technical responsibilities as well as managerial responsibilities over a small team of software engineers and consultants supporting all R&D Informatics needs.  The Senior Manager will be expected to directly contribute to software development, requirement gathering/ prioritization, data integration, ELN workflows, AI/ML implementation, and informatics system improvements, while also mentoring and guiding their team.

Additionally, this role will manage vendor relationships, drive AI/ML adoption, and oversee the R&D Informatics Helpdesk to ensure seamless support across the organization. This position reports to the VP, IT/Informatics.

Key Responsibilities:

Strategic Leadership & Hands-On Contribution:

  • Develop and execute an R&D informatics strategy, aligned with Prime Medicine’s R&D operational goals.
  • Lead and manage a small team of software engineers and consultants supporting informatics needs across all R&D including Computational Science, Sequencing Screening teams.
  • Provide hands-on contributions in scientific software development, informatics platform configuration, and AI/ML-driven data analytics.
  • Drive the adoption of innovative informatics solutions, including AI/ML-driven automation and data insights.
  • Evaluate emerging technologies and trends to ensure informatics capabilities remain at the forefront of industry advancements.

Workflow, Software Development & Process Optimization:

  • Oversee the design and development of computational tools, data pipelines, and software solutions to support R&D teams.
  • Lead workflow and process mapping across departments to optimize data flow and scientific operations.
  • Personally contribute to software and data engineering efforts, ensuring that tools are robust, scalable, and aligned with research objectives.
  • Ensure that data models and templates are scalable, efficient, and AI/ML-ready, enabling predictive analytics and automation.

Data Management, AI & Advanced Analytics:

  • Oversee the capture, structuring, and analysis of R&D data using Benchling, Spotfire, and other relevant platforms.
  • Develop and implement strategies for automated data ingestion, integration, and AI-powered analytics to ensure data consistency and integrity.
  • Collaborate hands-on with computational biologists, sequencing experts, and data scientists to develop AI/ML-based solutions for scientific data analysis.
  • Establish best practices for structured data storage, governance, and retrieval to support AI/ML model training and deployment.

Vendor & System Management:

  • Serve as the primary contact for informatics and AI/ML vendors, managing relationships and negotiating contracts to ensure cost-effective and high-quality solutions.
  • Partner with software providers to enhance product functionality based on R&D and AI/ML needs.

Informatics Helpdesk & Support:

  • Oversee and enhance the R&D Informatics Helpdesk, ensuring timely and effective issue resolution for internal teams.

Cross-Functional Collaboration:

  • Act as a liaison between IT, Research, Data Science, and other business units to ensure informatics solutions are seamlessly integrated into broader organizational processes.
  • Work directly with AI/ML teams to ensure models are trained on high-quality data and deployed effectively within R&D workflows.

Compliance & Best Practices:

  • Ensure all informatics and AI/ML-driven solutions comply with regulatory requirements (e.g., GxP, FDA, 21 CFR Part 11, GDPR) and industry best practices.
  • Stay informed about AI/ML ethics, data privacy standards, and regulatory guidelines for machine learning in life sciences.

Qualifications:

Required Qualifications:

  • Bachelor’s or Master’s degree in Informatics, Computer Science, Data Science, AI/ML, Bioinformatics, or Life Sciences.
  • Deep expertise in Benchling, Spotfire, or similar R&D informatics platforms.
  • Experience leading a team of software engineers and consultants supporting computational science, sequencing, and screening efforts.
  • Hands-on experience with scientific software development, AI/ML model implementation, or data engineering in biotech/pharma R&D.
  • 5+ years of experience in scientific informatics, data management, or AI/ML applications for R&D.
  • Strong background in workflow/process mapping, data modeling, and analytics.
  • Experience managing external vendors and contracts.
  • Demonstrated leadership abilities, including team mentorship, stakeholder engagement, and project management.
  • Excellent communication and collaboration skills, with an ability to translate technical needs into actionable informatics strategies.
  • Strong problem-solving skills and attention to detail.

Preferred Qualifications:

  • Experience in the biotechnology or pharmaceutical industry with a deep understanding of R&D workflows, preferably within a cell and gene therapy environment.
  • Familiarity with AI/ML model development, cloud-based computing platforms (AWS, Azure, Google Cloud), and data engineering pipelines.
  • Prior experience in a managerial or leadership role within R&D informatics.
  • Knowledge of FAIR data principles and how they apply to AI/ML model training and deployment.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Apply for this job

*

indicates a required field

Resume/CV*

Accepted file types: pdf, doc, docx, txt, rtf

Cover Letter

Accepted file types: pdf, doc, docx, txt, rtf

Education

Select...
Select...
Select...
Select...
Select...
Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Prime Medicine’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Select...
Select...
Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Select...

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury
Select...

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.