Co-op: Small Scale Guide RNA Chemistry

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Fall 2026 Co-op: Small Scale Guide RNA Chemistry

Co-op Assignment Overview

Prime Medicine is seeking a Co-op for the Fall 2026 semester to join our guide RNA chemistry team. The ideal candidate will have a strong foundation in chemistry or biochemistry and will contribute to the synthesis, cleavage and deprotection, purification, and analysis of long guide RNA oligonucleotides. In this role, you will gain comprehensive, hands-on experience in solid-phase synthesis, purification, desalting, lyophilization, and analysis of long oligonucleotides in direct support of our prime editing programs.

Primary Responsibilities

• Support solid-phase synthesis of oligonucleotides using automated DNA/RNA synthesizers, including the Mermade12
• Assist with HPLC purification and UPLC/LC-MS analysis of research-scale long oligonucleotides
• Prepare buffers and solutions for guide RNA purification and analysis
• Track and manage inventory of chemicals, reagents, and consumables, including coordinating orders as needed
• Assist with the maintenance and troubleshooting of laboratory equipment, including synthesizers, SpeedVacs, lyophilizers, and HPLC instrumentation
• Maintain thorough and accurate records in an electronic laboratory notebook (ELN); track progress, analyze and interpret data, and present findings to both the immediate team and cross-functional stakeholders
• Conduct all laboratory work safely and efficiently, upholding a safe working environment for all colleagues

Qualifications

• Currently pursuing a B.S. in Chemistry, Biochemistry, or a related field; a foundational understanding of organic chemistry is preferred
• Prior hands-on experience in a chemistry or biochemistry laboratory
• High degree of self-motivation and adaptability in a fast-paced environment, with strong organizational skills and the ability to prioritize tasks and meet deadlines
• Proficiency in common computer applications, including Microsoft Excel, Word, and PowerPoint
• Strong troubleshooting and communication skills
• Demonstrated ability to work both independently and collaboratively within a team

Preferred Qualifications

• Prior experience in nucleic acid chemistry
• Hands-on experience with HPLC, UPLC, and/or LC-MS instrumentation

What We Offer

• A collaborative, cutting-edge team committed to mentorship and professional networking
• Full reimbursement of monthly commuting costs, including MBTA, Commuter Rail, Bluebikes, and more
• Participation in regular seminars featuring industry experts
• Full access to employee programming, including learning and development initiatives, social events, and more

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.