Director, Patient Advocacy & Medical Affairs

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Job Title

Director, Patient Advocacy & Medical Affairs

Reports To

VP of Clinical Development

Position Summary

Prime Medicine is seeking an Associate Director or Director, Patient Advocacy & Medical Affairs to lead patient-focused engagement across our rare disease gene-editing programs. This role is central to ensuring that the patient voice meaningfully informs development strategy, clinical trial design, and external engagement, while also supporting Medical Affairs activities with credible, patient-grounded insights.

The successful candidate will build trusted relationships with patient communities, advocacy organizations, caregivers, and clinicians, and will work cross-functionally with Clinical Development, Medical Affairs, Regulatory, and Communications teams. This is a highly collaborative role for a leader who combines deep empathy and credibility with patients and a strong understanding of medical, scientific, and regulatory contexts.

Key Responsibilities

Patient Advocacy Leadership

• Serve as the primary internal advocate for patients and caregivers across rare disease programs.
• Build and maintain long-term, trust-based relationships with:
• Patient advocacy organizations
• Patient leaders and caregivers
• Community groups and foundations
• Ensure patient perspectives are integrated into:
• Clinical trial design and execution
• Endpoint selection and feasibility considerations
• Study materials and participant experience
• Lead patient advisory boards, listening sessions, and community engagements in a compliant and transparent manner, including oversight of sponsorship activities and events as well as inquiry tracking.
• Partner with cross-functional teams to incorporate patient insights into development decisions.

Medical Affairs Partnership & Support

• Collaborate closely with internal teams to:
• Support external scientific engagement with healthcare professionals and key opinion leaders
• Ensure patient-focused insights inform medical strategy and external education
• Contribute to the development and review of:
• Medical and scientific communication materials
• Patient-facing educational resources
• Advocacy-appropriate disease and treatment education content
• Support congress planning, advisory boards and patient panels, and non-promotional medical education activities with a patient-centered lens.

Clinical Development & Cross-Functional Collaboration

• Partner with Clinical Development and Clinical Operations to:
• Provide patient-centric input on protocol design, inclusion/exclusion criteria, and visit burden
• Improve trial awareness, access, and participant experience
• Support regulatory interactions and briefing materials by articulating patient needs and unmet burden.
• Collaborate with Regulatory and Legal teams to ensure advocacy activities are compliant and aligned with company values.

Strategy, Insights & Impact

• Monitor and synthesize patient community insights, unmet needs, and emerging trends across relevant rare diseases.
• Translate patient insights into actionable recommendations for leadership and program teams.
• Help shape long-term patient engagement strategy as programs advance through development.
• Represent the company externally as a credible, compassionate, and scientifically grounded partner to the patient community.

Qualifications

Required

• Bachelor’s degree required; advanced degree (Master’s, PhD, PharmD, MD, MPH) preferred.
• 15+ years of experience in patient advocacy, medical affairs, rare disease engagement, or related roles within biotech, pharma, federal or nonprofit settings.
• Demonstrated experience working directly with patient advocacy organizations and patient communities.
• Strong understanding of clinical development and medical affairs in rare diseases.
• Excellent communication skills, with the ability to translate complex science into patient-appropriate language.
• Proven ability to collaborate cross-functionally in a fast-paced, mission-driven environment.

Preferred

• Experience in gene therapy, gene editing, or other advanced modalities.
• Industry experience supporting early-stage clinical programs.
• Familiarity with regulatory and compliance considerations for patient engagement.
• Background in rare genetic diseases.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.