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Director, Nonclinical Safety

Cambridge, MA

Relay Therapeutics is seeking a motivated and passionate Director of Nonclinical Safety who is looking to have a broad and tangible impact on drug discovery and development.  Reporting into the VP, Head of Nonclinical Safety, this role will support the advancement of Relay’s broad pipeline in oncology and rare genetic diseases. 

Your Role

  • Develop and implement strategies to support lead optimization and candidate selection efforts of small molecules and targeted protein degraders
  • Conduct target safety assessments to assess the benefit-risk of targets early in the drug discovery process
  • Work closely with Nonclinical operations to coordinate, design, monitor and manage external toxicology studies
  • Represent Toxicology in multifunctional discovery and early development project teams; integrate, summarize and effectively communicate complex data  
  • Collaborate with key stakeholders and project team members to support drug discovery and development
  • Contribute to the cross-functional review of regulatory documents and author and review Toxicology sections for relevant regulatory documents
  • Initiate, lead and champion innovations to ensure relevant cutting-edge science is applied to project-related issues
  • Contribute to a team culture that promotes fearlessness, inclusion, candor and craftmanship

Your Background

  • PhD in Toxicology, Pharmacology or related sciences (e.g, DVM) and a minimum of 10+ years of industry experience in Toxicology (DABT certification preferred)
  • Ability to work effectively with Discovery Research teams in support of small molecule and protein degrader lead optimization and development candidate nomination strategies
  • Strong knowledge in Toxicology study design, monitoring, data interpretation, and their integration in support of drug development. 
  • Track record of applying a 3Rs-centered and welfare-oriented approach to animal-based research
  • Familiar with developing and managing relationships with CRO partners
  • Clear written and oral communication skills and the ability to distill complex data sets for team discussions and regulatory deliverables 

#LI-ASM1

About Relay Therapeutics

Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process.  

Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you’re excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us! 

 

 

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