Invivo Translational Scientist / Senior Research Associate(CONTRACT BOS/CAMBRIDGE BASED ONLY)

Company Summary: 

Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of self-assembly nanostructures by exploiting a family of naturally occurring commensal viruses to create the first re-doseable and targetable medicines utilizing a variety of payloads, such as oligos, small molecules, and DNA. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need.

Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Seres Therapeutics (NASDAQ:MCRB), , , and Indigo Agriculture.

Summary of Role:

We are seeking a highly motivated In Vivo Pharmacology Translational Scientist / Senior Principle Research Associate with an oncology background to work as part of a highly collaborative, fast paced team.  The successful candidate will independently execute complex preclinical in vivo oncology studies. They will design, execute, and interpret efficacy, PK, and PD in vivo studies that drive translational decision-making across our pipeline. This role is hands-on requiring advanced technical expertise, is highly collaborative, ideal for a scientist who thrives in a dynamic startup environment and is passionate about turning data into actionable insights.

You will work closely with discovery, biology, and translational teams to establish robust in vivo models, generate high-quality data, and support target validation and candidate progression.

 Key Responsibilities

• Design, plan, and execute complex in vivo oncology studies (including model development, efficacy, PK/PD, and mechanism-of-action studies) to support discovery and translational objectives
• Develop and optimize disease-relevant animal models aligned with human biology and clinical hypotheses
• Manage study execution, timelines, and logistics with minimal oversight, ensure complete, accurate and timely data capture and documentation.
• Perform hands-on in vivo procedures, including tumor implantation and measurement, dosing (IP, IV IM, SC), sample collection, and tissue processing
• Utilize a range of tumor models including xenograft, syngeneic and orthotopic models
• Analyze, interpret, and clearly communicate in vivo data to guide project decisions
• Collaborate cross-functionally with in vitro biology, bioinformatics, chemistry, and external partners
• Contribute to translational strategies, biomarker identification, and hypothesis-driven study design
• Maintain high standards of experimental rigor, documentation, and reproducibility
• Execute all work in compliance with IACUC and institutional polices
• Support CRO oversight, study planning, and data review where appropriate

Required Qualifications

• BSc, MSc, or PhD in Biology, Pharmacology, Biomedical Sciences, or a related discipline
• Hands-on experience with in vivo models in an academic or industry setting
• Strong understanding of translational biology and how in vivo data informs human disease
• Experience with animal handling, dosing, imaging and necropsy procedures
• Ability to independently plan experiments and troubleshoot challenges
• Strong data analysis, record-keeping, and scientific communication skills

Preferred Qualifications

• Industry experience in biotech or pharma
• Experience supporting immune-oncology programs and immune modulating modalities
• Hands on experience with xenograft and orthotopic tumor models in immunocompromised and humanized mouse strains
• Experience with in vivo bioluminescence and fluorescence imaging is highly desirable.
• Experience with GraphPad Prism for in vivo data analysis and visualization
• Experience with PK/PD studies, biomarkers, or translational endpoints

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.