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Clinical Pharmacologist (Senior Manager or Associate Director)

New York; Cambridge, MA

We are looking to hire a Senior Manager/Associate Director of Clinical Pharmacology to join us in our mission to discover and develop drugs that improve human health through the use of breakthrough computational methods. We are seeking outstanding individuals to join our drug discovery group and contribute to our rapidly expanding portfolio of drug discovery programs and collaborations.

Our drug discovery and early clinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. The group is enhanced by more than 100 software developers and engineers as well as a large-scale compute infrastructure to apply our proprietary physics-based drug design and optimization platform. Several programs we have worked on have achieved Development Candidates, including progression to clinical development and FDA approval. You can view our entire pipeline of wholly-owned programs and collaborations here. 

Who will love this job:

  • A Clinical Pharmacology and Pharmacometrics enthusiast with a deep passion for application of clinical pharmacology and model-informed drug development (MIDD) in drug development and dose optimization
  • An analytical mind who excel in data analysis, modeling, and simulation techniques to apply their analytical skills to inform decision-making in drug development
  • A collaborator who enjoys working with cross-functional teams and shaping the strategic direction of drug development programs
  • A problem-solver who likes tackling challenges and finding creative solutions
  • An excellent communicator who can utilize soft skills to guide, lead, and influence strategy/direction of programs
  • A drug development veteran who can lead and motivate cross-functional teams
What you will do:
  • Develop and execute clinical pharmacology strategies to support drug development programs, ensuring alignment with overall clinical development plans
  • Collaborate with cross-functional stakeholders including DMPK, translational medicine, clinical development, clinical operations, regulatory, CMC, and project management to ensure completion of clinical pharmacology deliverables
  • Act as the lead clinical pharmacologist on study teams to support clinical development
  • Lead the planning, design, execution, analysis, and reporting of clinical pharmacology studies (such as food effect, BA/BE, human ADME, drug interactions, renal and hepatic impairment, etc.)
  • Represent the department as a subject matter expert on cross-functional project teams and be able to influence team strategy
  • Author and review relevant sections of clinical study protocols, analysis plans, and study reports
  • Contribute to regulatory submissions and health authority agency interactions relevant to clinical pharmacology
  • Plan and perform data analyses, including NCA, population PK and PK/PD analyses, and exposure-response analyses, and use MIDD approaches for efficient clinical development of assets
  • Develop in-house standards, process, work instructions and SOPs for clinical pharmacology and pharmacometric analyses
What you should have:
  • PhD, PharmD, or equivalent in Life Sciences, Clinical Pharmacology, Pharmacokinetics, pharmaceutical sciences, or a related field
  • Three to five years of experience in clinical pharmacology and pharmacokinetic-pharmacodynamic modeling within the pharmaceutical or biotechnology industry
  • Robust knowledge of concepts in pharmacokinetics, pharmacodynamics, translational sciences and PK/PD data analyses
  • Hands-on experience and knowledge of standard PK and PD data analysis softwares such as Phoenix, R/R Studio, Monolix, NONMEM etc
  • Proven track record of successful contributions to drug development programs as a clinical pharmacologist
  • Knowledge of various clinical pharmacology regulations and guidelines and data standards requirements for clinical pharmacology and data management standards
  • Experience in oncology drug development is a plus
 
Pay and perks:
Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have regular catered meals in the office, a company culture that is relaxed but engaged, and over a month of paid vacation time.  Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces. 
 
Sound exciting? Apply today and join us!
 
Estimated base salary range: $150,000 - $220,000 (NYC only). Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team.
 
As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.

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