Principal Scientist, Chemistry

Seaport Therapeutics is a clinical-stage biopharmaceutical company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary Glyph^TM technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and are guided by an extensive network of renowned scientists, clinicians and key opinion leaders. For more information, please visit www.seaporttx.com.

Seaport Therapeutics is seeking an outstanding synthetic medicinal chemist to take a key role in advancing preclinical discovery in its Glyph™ technology platform. The scientist will be responsible for the design, synthesis and characterization of novel lipid prodrugs as part of our Glyph prodrug platform. The ideal candidate will demonstrate a commitment to fostering a collaborative and innovative culture that embodies our values of service by engaging in research that prioritizes the well-being of those impacted by mental health conditions, with a “we own it” mentality that exhibits an entrepreneurial mindset and dedication to scientific excellence, while increasing happiness and bringing out the best in each other “as a team”.

  Some of the more critical responsibilities will include:

• Design of new prodrugs based on analysis of existing and newly generated data
• Planning and implementation of synthetic routes to new prodrugs
• Managing CRO-based discovery chemistry and discovery process chemistry teams
• Coordinate the planning, execution, and management of workflows for in vitro and in vivo assessment of new prodrugs
• Analyze and interpret experimental data, presenting findings with scientific insights to facilitate informed decision-making.
• Execute research projects independently, and ensure that projects support current company goals
• Actively participate in project team meetings, and contribute to reports, scientific publications, patent applications, and regulatory filings

Experience

• PhD. in synthetic organic chemistry (or equivalent) + 5-8 years industry experience within a biotech or pharmaceutical organization
• A published record of scientific achievement from the lab demonstrated with peer-reviewed publications, and/or patent inventorship
• Prior experience with managing CRO-based synthesis is required
• Experience with lipid chemistry, prodrug chemistry, bioconjugation or ADC chemistry is desirable
• Familiarity with ADME/pharmacokinetics/pharmacodynamics in a drug discovery setting is valued
• Highly motivated and results driven individual with a passion for working in a fast-paced and evolving organization
• Outstanding communication, interpersonal, and partnering skills
• Excellent cross-disciplinary skills in communicating scientific ideas to non-scientist stakeholders to foster collaboration and deliverable-based teamwork
• Startup experience is highly valued. Ability to adjust rapidly to changing scientific priorities and technologies
• Ability to work onsite in Boston at least 3-4 days per week