New

Director, Pharmacometrics

South San Francisco, California, United States

 

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.

We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.

We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.

For more information see: www.septerna.com.

THE ROLE

The Director, Pharmacometrics will be responsible for establishing and leading the pharmacometric function, as part of the Drug Metabolism Pharmacokinetics and Clinical Pharmacology Department.  He/She will provide scientific and strategic leadership to apply modeling and simulation approaches in drug discovery and development.  This role will partner closely with Research, Translational, Clinical, and Regulatory teams to develop quantitative approaches in drug development.

Responsibilities:

  • Lead the design and execution of pharmacometric strategies across all stages of development.
  • Utilize PK/PD, PBPK, population PK modeling approaches to support internal decision-making on drug candidates.
  • Serve as a key subject matter expert for pharmacometric components of clinical protocols, regulatory filings (IND, CTA, briefing documents), and global health authority interactions.
  • Manage external consultants and CROs conducting pharmacometrics work.
  • Act as a strategic thought partner across functions to influence program-level and portfolio-level development decisions.
  • Stay current with regulatory guidance and scientific advances in modeling and simulation.

Qualifications 

  • PhD. in pharmacometrics, pharmacokinetics, clinical pharmacology, or a related field, with 10+ years of experience in the pharmaceutical or biotechnology industry.
  • Demonstrated leadership in pharmacometric strategy and successful regulatory interactions (e.g., IND, EOP1/2, NDA/BLA support).
  • Expert knowledge of population PK/PD modeling, simulation, and quantitative pharmacology principles.
  • Proficiency with software tools such as Gastroplus, Phoenix NLME, NONMEM, or other pharmacometrics modeling platforms.
  • Proven ability to work in cross-functional teams and influence key development and regulatory decisions.
  • Experience in leading pharmacometric functions in a biotech or pharma setting is strongly preferred.
  • Excellent scientific communication, leadership, and organizational skills.
  • Ability to operate effectively in a dynamic and entrepreneurial environment.

The anticipated salary range for candidates who will work in South San Francisco, CA is $225,000 - $245,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. 

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

 

 

 
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.  We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.  Septerna participates in the E-Verify program.  California Consumer Privacy Act Privacy Notice For Job Applicants.  If you are a California resident, click here for our CCPA Notice.

 

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