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Scientist II, LNP Analytics

Cambridge, Massachusetts, United States

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking an intellectually curious and collaborative Scientist, who will lead the analytical development and characterization efforts for lipid nanoparticles (LNPs) for in vivo delivery of genome engineering material. The candidate will be responsible for spearheading analytical development activities and providing analytical support to the Delivery team from bench scale to Phase I GMP manufacture of lipid nanoparticle drug products. This position will interface cross-functionally with the cross-functional teams to progress new in vivo genetic medicines through the pipeline.

Key Responsibilities & Accountabilities:

  • Leverage expertise in lipid chemistry, LNP formulation and analytical characterization to advance novel in vivo genetic medicines across different stages of drug development
  • Develop methods such as DLS, MALS, UPLC, HPLC-CAD, IP-RP HPLC, LC-MS/MS, CGE, BLI/SPR, ELISA and ddPCR/qPCR to screen and support optimal LNP formulations for in vitro and in vivo applications
  • Author standard operating procedures, study plans and reports and present findings at cross-functional team meetings
  • Work in close collaboration with the discovery team to support in vitro and in vivo experiments assessing biodistribution, safety and efficacy of LNP formulations
  • Stay current with the latest developments in LNP technology, proposing enhancements to the company's development efforts, as appropriate
  • Plan, organize, coordinate, and lead activities to ensure progress of internal and external projects and their compliance to phase appropriate cGMP and standard operating procedures (SOPs)

Qualifications & Skills:

  • PhD in a related field (e.g., biochemistry, chemical engineering, or materials science) with 2-4 years of industry/academic experience focusing on LNP formulation
  • Prior experience with characterization of targeted nanoparticles is strongly preferred
  • Strong foundation in lipid chemistry, formulation development and analytical techniques
  • Familiarity with gene editing modalities or nucleic acid delivery (e.g. CRISPR/Cas, base editing, mRNA, DNA) is a plus
  • Demonstrated experience working in a fast-paced, innovative environment
  • Ability to work collaboratively across teams to meet project deliverables and timelines
  • Strong communication, leadership and decision-making skills

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