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Senior Research Associate, in vivo Pharmacology

Cambridge, Massachusetts, United States

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking a highly motivated and collaborative Senior Research Associate to join our in vivo Pharmacology team. In this role, the Senior Research Associate will perform hands-on in vivo studies utilizing murine oncology and non-oncology models, supporting the advancement of genetic medicines that leverage engineered recombinases delivered through non-viral methods. Working closely with cross-functional teams, this is a unique opportunity to work on the front lines of innovation and contribute to the advancement of transformational therapies.

Key Responsibilities & Accountabilities:

  • Develop and implement immuno-oncology preclinical anti-tumor efficacy and pharmacodynamic studies to evaluate recombinase-based engineering of immune cells
  • Culture and prepare tumor cells and PBMCs for injections; process samples for downstream analyses to support research objectives
  • Analyze and interpret data and produce study reports to inform project direction
  • Effectively communicate findings to internal teams
  • Adhere to SOPs and IACUC protocols
  • Maintain detailed and accurate laboratory records in compliance with data integrity and documentation standards 

Qualifications & Skills:

  • Master’s degree in Pharmacology, Immunology, Immuno-oncology, or a related field with 1+ years of relevant industry or academic experience, or a Bachelor’s degree with 3+ years of experience
  • Hands-on in vivo pharmacology expertise, including mouse handling, surgical procedures, IV tail vein injection, body weight monitoring, blood collection, tumor model development, tumor growth analysis, and tissue dissociation and processing
  • Demonstrated ability to execute, interpret, and troubleshoot in vivo studies
  • Experience with thawing and infusing T cells, PBMCs, or other immune cell types into mice as well as with culturing tumor cell lines and establishing tumor models in vivo is preferred
  • Demonstrated ability to work independently and effectively with teammates in a laboratory setting; curiosity to learn new techniques and multitask effectively
  • Experience maintaining meticulous records, including documenting and maintaining an organized lab notebook, lab inventory, and experimental results
  • Excellent communication skills, with a team-first mindset and the ability to convey technical information
  • Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment

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