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Director, Molecular & Cellular Immunology

Cambridge, Massachusetts, United States

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking an innovative, intellectually curious, and team-oriented Director, Molecular & Cellular Immunology to apply their deep immunology expertise and problem-solving abilities to collaboratively develop non-viral in vivo CART therapies. Reporting to the SVP, Immunology, this individual will lead the Molecular & Cellular Immunology team, with accountability for the execution of in vitro workflows in support of deepening our mechanistic understanding of the Stylus platform applied to immune cells, innovating within the platform, progressing the lead CART program to development candidate nomination, and preparing for advancement to clinic. This role is expected to serve as a close scientific thought partner with the SVP of Immunology, an effective collaborator with members of the broader scientific team, and a key driver in our mission to revolutionize the field of in vivo immune therapy.

Key Responsibilities & Accountabilities:

  • Conceptualize in vivo T cell therapeutic product candidates applying Stylus non-viral recombinase engineering platform and build molecular designs to realize these product concepts
  • Develop experimental strategies and immune cell-based testing systems to rigorously evaluate product candidate functional performance for development candidate nomination and preclinical data package generation
  • Work closely with direct reports to focus experimental design and execution on solving key questions and scientific problems for the lead program and innovations, with hands-on lab contributions as necessary
  • Lead, manage, mentor, and develop team of direct report scientists
  • Apply immunology expertise in collaborative work with multi-disciplinary team members and external partners to execute programs consistent with overall strategy
  • Communicate scientific concepts, strategies, status updates, and experimental results across the organization and to various high-level stakeholders
  • Drive and deliver results with speed and rigor with timeline, milestone, and budgetary awareness
  • Actively monitor the latest literature and technologies in the field to inspire or inform innovation and present Stylus data externally as appropriate
  • May lead or manage collaborations with external partners ranging from academic, CROs and corporate entities to advance programs

Qualifications & Skills:

  • PhD in Molecular or Cellular Biology, Virology, Immunology or related field of study with deep Immunology expertise
  • 8+ years of post-graduate experience with a minimum of 5 years of drug discovery experience in the pharmaceutical and/or biotechnology industry
  • Proven track-record of leading programs in immunology, immunotherapy or engineered immune cell therapy from early drug discovery to IND, with experience in CART
  • A clear track record of accomplishment as demonstrated by clearly identifiable achievements such as patents, new initiatives, IND preparation, and publications
  • Demonstrated expertise in immune-modulating molecule design and application of design-test-optimize cycles for functional evaluation of immune-relevant gene and cell therapy cargos
  • Previous experience in the areas of T cell engaging bispecific antibodies and antibody discovery is preferred
  • Experience managing and developing scientists as direct reports
  • Ability to excel in internal and external cross-functional collaborations
  • Ability to think critically, extract and synthesize simple principles from complex datasets and communicate them effectively

Pay Range: $225,000-$240,000

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