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Associate Scientist, Automation

Cambridge, Massachusetts, United States

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team and build automation capabilities that accelerate the development of our next-generation gene editing tools. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. This individual will play a key role in discovery and engineering efforts, advancing recombinase-based genome editing platforms and collaborating across diverse R&D teams.

Key Responsibilities & Accountabilities: 

  • Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows
  • Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT)
  • Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products
  • Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens
  • Coordinate DNA synthesis and reagent orders with external vendors
  • Manage raw material, plasmid, and RNA inventories
  • Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks
  • Present findings clearly to other teams and contribute to scientific discussions and decision-making

Qualifications & Skills:

  • BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field
  • Experience with automated liquid handling systems (e.g., Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting
  • Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus
  • Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
  • Hands-on molecular biology experience, including cloning and RNA production and purification
  • Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling
  • Experience with laboratory inventory management
  • Track record of generating precise, reproducible data and performing rigorous quantitative analysis
  • Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences
  • Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects
  • Strategic thinker who effectively plans and prioritizes to maximize scientific impact
  • Collaborative mindset with a team-first attitude
  • Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty

Pay Range: $105,000 - $120,000

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