Senior Manager, Data Scientist

About Summit:

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including:

Non-small Cell Lung Cancer (NSCLC)

• HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

• HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

• HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC)

• HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

Overview of Role:

The Senior Manager, Data Scientist role is part of the Commercial Operations team supporting the U.S. Business Unit—which includes, but is not limited to, Sales, Marketing, and Market Access. This team enables key business functions and strategic initiatives through data integration, reporting, and advanced analytics.

This position provides a unique opportunity for broad exposure across the U.S. commercial organization by contributing to the development of advanced analytics solutions. A core focus of the role will involve executing analytics on a variety of data sources—including patient claims, EDI shipment data, and unstructured datasets—as well as supporting future machine learning initiatives.

Role and Responsibilities:

• Design and implement advanced analytical models (e.g., predictive modeling, segmentation, optimization, machine learning) using diverse datasets such as claims, outlet-level sales data, EDI, hub data, real-world data (RWD), specialty pharmacy/distributor data, EMR, and internal commercial datasets.
• Develop and validate algorithms to identify patient journeys, adherence patterns, and treatment pathways.
• Contribute to an evolving data science practice, including problem framing, data exploration and preparation, data integration, machine learning model development, and production.
• Create scoring frameworks (e.g., HCP opportunity models, payer access risk scores, patient conversion likelihood).
• Build statistical and machine learning models for both proof-of-concept and production environments using Python, R, and SQL.
• Partner with stakeholders across the U.S. commercial teams to translate business needs into data-driven and machine learning solutions.
• Communicate advantages, limitations, and implications of analytical approaches to non-technical audiences.
• Share technical insights and solutions through design reviews, pair programming, code/model reviews, and team knowledge-sharing sessions.
• Conduct exploratory analysis of new datasets, generate descriptive statistics, identify trends and insights, and propose data engineering opportunities for integration.
• Utilize one or more commercial or open-source analysis platforms daily (e.g., Jupyter Notebook, RStudio, Posit, Microsoft Azure, Neo4j).
• All other duties as assigned.

Experience, Education and Specialized Knowledge and Skills:

• Experience in biotech, pharmaceuticals, or life sciences required
• Bachelor’s degree in Data Science, Computer Science, Mathematics, or a related field required; advanced degree preferred.
• Minimum 5+ years of relevant experience with a bachelor’s degree, or 3+ years with a master’s degree, contributing to or executing data science projects. Industry experience in customer behavior prediction, customer journey analytics, marketing analytics, or social network analysis is preferred.
• Demonstrated proficiency in Python and/or R.
• Strong SQL skills with hands-on experience working with relational databases; experience with graph databases and Cypher is a plus.
• Familiarity with machine learning and statistical modeling techniques
• Strong communication and cross-functional collaboration skills
• Experience developing solutions using text analytics, customer journey analytics, marketing analytics, or recommendation engines.
• Proven ability to explain statistical and machine learning concepts to business stakeholders in clear and meaningful terms.
• Knowledge of statistical and data mining techniques such as hierarchical clustering, network analysis, regression, random forests, text mining, NLP, and data visualization.

Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation.

Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summit’s Talent Acquisition team at recruiting@smmttx.com to obtain prior written authorization before referring any candidates to Summit.

Summit Therapeutics Inc. is an Equal Opportunity Employer and takes pride in creating and maintaining diverse environment. We do not discriminate in recruitment, hiring, training or promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.