Executive Director, FP&A

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Tango Therapeutics is seeking an experienced and strategic finance leader to serve as Executive Director, FP&A. Reporting directly to the SVP, Finance, this highly visible role will drive enterprise-wide financial planning & analysis strategy and execution, partnering closely with the executive team and Global Program Teams as Tango's pipeline and organization continue to scale.

This role offers the opportunity to build and lead a growing FP&A function, sharpen the rigor of the company's budgeting, forecasting, and long-range planning processes, and play a pivotal role in supporting Tango's evolving development organization through its next stage of growth.

Your Role:

As Executive Director, FP&A, you will lead enterprise-wide FP&A strategy and execution in partnership with the SVP, Finance. You will serve as a member of the Global Program Teams, ensuring alignment across functions on strategy execution and resourcing, and will partner closely with Clinical Operations to sharpen clinical trial forecasting as the development organization grows. You will lead and develop the FP&A function, initially overseeing a team of two, building scalable FP&A capabilities and processes to support a growing, increasingly complex organization.

• Drive enterprise-wide FP&A strategy and execution in close partnership with the SVP, Finance
• Lead the Annual Operating Plan (AOP), quarterly reforecasts, and Long-Range Plan (LRP), adding depth, discipline, and rigor to the budgeting and planning process
• Partner with Clinical Operations to sharpen clinical trial forecasting and support increasingly complex, late-stage development budgets
• Serve as the Finance representative on Global Program Team(s) (GPTs), ensuring cross-functional alignment on execution of strategy and appropriate resourcing
• Assess the financial impact of strategic changes, drive scenario planning, and deliver insights and analyses that support decision-making across the leadership team
• Lead cash runway and burn-rate analysis to inform capital planning and support strategic decision-making by the executive team and Board
• Develop and support materials for the Board of Directors and executive leadership on financial performance, forecasts, and key business drivers
• Convert R&D and clinical program assumptions into financial and headcount forecasts across the pipeline, in partnership with Clinical and Program Management
• Provide financial modeling and analytical support for business development, licensing, and other corporate development opportunities as they arise
• Partner with Accounting on the monthly/quarterly close process and budget-to-actual variance analysis to ensure accurate, timely financial reporting
• Build and refine scalable FP&A processes, systems, and tools to support a growing and increasingly complex organization
• Provide early-stage commercial finance support and analysis, bridging near-term needs ahead of a dedicated commercial finance function
• Lead, mentor, and develop the FP&A team optimizing resource planning and building a high-performing function that can scale with the organization
• Partner with cross-functional leaders across R&D, Clinical, Commercial, and Corporate functions to deliver timely, accurate, and actionable financial insights

What You Bring:

• Bachelor’s degree in Finance, Accounting, or a related field required; MBA and/or CPA preferred
• 15+ years of progressive Finance and FP&A experience, including significant leadership experience within the biotechnology or pharmaceutical industry
• Demonstrated experience with late-stage clinical trial budgeting and forecasting; pre-commercial finance experience is desirable
• Proven track record leading Annual Operating Plan, reforecast, and Long-Range Plan processes
• Experience with FP&A planning systems and ERP/procurement tools (e.g., Adaptive Insights, NetSuite) and building scalable financial processes to support organizational growth
• Experience leading, mentoring, and developing a team of finance professionals
• Strong business partnering skills, with experience supporting cross-functional teams such as Global Program Teams, Clinical Operations, and Commercial
• Demonstrated experience partnering with and presenting financial insights, forecasts, scenarios, and recommendations to executive leadership and board members
• Experience with cash flow and runway modeling in a clinical-stage biotech or pharmaceutical environment
• Solid understanding of the drug development lifecycle, from early research through clinical development and toward commercialization
• Excellent analytical, scenario-planning, and communication skills, with the ability to translate complex financial data into actionable insights for executive leadership
• Resourceful, adaptable, and execution-oriented, with the ability to operate effectively in a fast-paced, evolving organization

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We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.