Research Associate/Senior Research Associate, mRNA Process Development (downstream)

Your experience includes… 

• BS/MS with 1-3 years of experience in Biochemistry, Molecular Biology, Chemistry, Analytical Chemistry, or related discipline.
• Technical understanding and experience in mRNA process development including mRNA synthesis, purification and analysis.
• Hands-on experience with mRNA in vitro transcription (IVT).
• Hands-on experience with downstream purification technologies (AKTA, TFF), preferably in the context of mRNA.
• Understanding of nucleic acid biochemistry, enzymatic and chemical reactions, PCR reaction, plasmid processing, and standard analytical techniques for macromolecules is preferred.
• Track record of completing deliverables within specified timelines.
• Eager to work with highly skilled and dynamic teams in a fast-paced, entrepreneurial and technical setting
• The successful candidate should be collaborative, communicative, and passionate about the next generation of genetic medicines.

Preferred Qualifications…

• Experience in using analytical technologies including nanodrop, Tape station, Lunatic, Fragment analyzer, capillary electrophoresis. 
• Experience with the development of downstream purification methods for mRNA.
• Experience with handling automated systems like Kingfisher, TECAN, Hamilton, or a desire to learn.
• Experience with Design of Experiment (DOE) statistical tools for process improvement.

You are interested in… 

• Develop and optimize mRNA downstream process of mRNA.
• Learn and execute automation instruments including liquid handlers (TECAN, Kingfisher) for automated high throughput miniature reactions and purification.
• Analyze mRNA quality by nanodrop, tape station, fragment analyzer etc.
• Support the generation of preclinical mRNA high quality material and collaborate with cross-functional teams.
• Maintain thorough electronic lab notebooks and documentation records (e.g. Benchling).
• Adhere to all laboratory safety requirements and procedures.

About you: 

Tessera Therapeutics is seeking a Research Associate/Senior Research Associate for RNA process development and innovation. You will support process development for in vitro transcription, modification, and purification of RNAs to support Tessera's pre-clinical efforts. We seek individuals who are proactive, enthusiastic, and show a passion for process development. The successful candidate should have strong communication and collaboration skills, attention to detail and excellent organizational and documentation skills.

Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence. 

Meet your Manager:

All inquiries regarding the posted position should be directed to the Talent Partner (see below). Interested individuals must apply directly to be considered for the opening. 

Ana Stringari De Castro – Scientist II, PD-RNA 

Born and raised in Brazil, Ana moved to the US to get her bachelor’s degree in chemical engineering. During undergrad, Ana demonstrated interest for academic research, which motivated her to pursue a Ph. D at the Georgia Institute of Technology, where she focused on the design and synthesis of protein-based vaccines. During this time, Ana had the opportunity to gain expertise in molecular biology techniques, protein expression and purification systems, and analytical assays. Ana has been working in the gene therapy field since 2021 as a process development scientist. Ana has been with Tessera for over 1 year as part of the RNA Process Development team and has been involved in the planning and execution of several large-scale production batches. Outside of work, you can find Ana running along the Charles River.

Meet your Talent Partner:

Narissa Furtado-Cordeiro - Manager, Talent Acquisition 

Narissa joined the Biotechnology industry shortly after graduating with her BS in Marketing from Franklin Pierce University. She is currently pursuing a MS in Legal Studies from Northeastern University School of Law while working full time as a Manager in Talent Acquisition at Tessera. She is passionate about helping individuals find a fulfilling opportunity while considering their interests, aspirations and technical skills. Narissa lives in Northern Vermont and enjoys spending time outdoors with her husband, three-year-old daughter and German Shepherd.

Tessera offers a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits currently include group medical, vision and dental coverage, group life and disability insurance, 401(k) with company contribution, tuition reimbursement, and much more.

Company Summary:

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

More about Tessera Therapeutics:

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. Tessera provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with Tessera regarding a reasonable accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied, please contact the recruiter or Accommodations@tesseratx.com

Recruitment & Staffing Agencies:  Tessera Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Tessera Therapeutics or its employees is strictly prohibited unless contacted directly by Tessera Therapeutics’ internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Tessera Therapeutics, and Tessera Therapeutics will not owe any referral or other fees with respect thereto.