Scientist I – Bioanalytical & Advanced Assay Development

About Tonix*

Tonix is a fully integrated biotechnology company, publicly traded on NASDAQ (ticker: TNXP), with marketed products and a pipeline of development candidates The Company is focused on commercializing, developing, discovering, and licensing therapeutics to treat and prevent human disease. In August 2025, Tonix received FDA approval for Tonmya™ (cyclobenzaprine HCl sublingual tablets), a first-in-class, once-daily, non-opioid treatment for fibromyalgia. Tonmya is the first new fibromyalgia therapy approved in over 15 years, following successful Phase 3 trials demonstrating significant symptom improvement. Commercial launch is expected in the fourth quarter of 2025. Tonix also markets Zembrace® SymTouch® (sumatriptan injection) 3 mg and Tosymra® (sumatriptan nasal spray) 10 mg, both indicated for the treatment of acute migraine with or without aura in adults.

Tonix’s development portfolio includes product candidates in central nervous system (CNS), immunology, immuno-oncology infectious disease and rare disease. The CNS pipeline features both small molecules and biologics to treat pain, neurologic, psychiatric, and addiction conditions. The immunology portfolio includes biologics to address organ transplant rejection, autoimmunity, and cancer. The infectious disease pipeline includes a vaccine in development to prevent smallpox and monkeypox, which also serves as a live virus vaccine platform for other infectious diseases. Finally, the rare disease portfolio includes a product in development for Prader-Willi syndrome, which has both orphan drug designation and rare pediatric disease designation grants from the FDA.

Tonix owns and operates a state-of-the art infectious disease research facility in Frederick, Md.

Please visit www.Tonixpharma.com for specifics on the pipeline.

*All of Tonix’s product candidates are investigational new drugs or biologics and have not been approved for any indication.

Position Overview

Tonix Pharmaceuticals is advancing a diverse portfolio of therapies, including antivirals, biologics, small molecules, and vaccines in infectious diseases and immunology. We are seeking a Scientist-II to expand our bioanalytical assay development capabilities, supporting programs from discovery through translational and regulatory milestones. This role provides the opportunity to design and validate robust bioanalytical and cell-based assays that directly support Tonix’s therapeutic pipeline, while generating high-quality data that drives preclinical and clinical decision-making

Key Responsibilities

 

 

 

 

• Bioanalytical Assay Development – Design, develop, optimize, and execute assays supporting potency, neutralization, immunogenicity, biomarker detection, ADME/DMPK, and oncology programs under guidance of senior scientists.
• Cell-Based Assay Development – Establish and refine functional 2D and 3D cell-based assays to evaluate biological activity, target engagement, and mechanism of action of therapeutic candidates.
• Organoid & iPSC Model Implementation – Culture, maintain, and characterize human organoids and iPSC-derived differentiated cell systems to support disease modeling, efficacy testing, and translational studies. Perform routine passaging, differentiation, quality control, and assay integration.
• 3D Culture & Bioprinting Support – Assist in development and optimization of 3D culture systems, bioprinted tissue constructs, and micro physiological models to improve physiological relevance of screening platforms.
• Computational & Data Skills for 3D Platforms
• Utilize image analysis software (e.g., Harmony, ImageJ/Fiji, CellProfiler, or equivalent) for quantitative phenotypic analysis
• Work with 3D reconstruction tools and segmentation algorithms for organoid/tissue models
• Manage bioprinting design files (e.g., CAD-based inputs, G-code workflows where applicable)
• Apply basic scripting (Python/R preferred) for data processing, visualization, and statistical analysis
• Biochemical & Biophysical Assays – Execute and optimize ELISA, MSD, enzymatic, binding, and label-free assays (e.g., Octet/BLI, SPR) to characterize potency, kinetics, and molecular interactions.
• Experimental Execution & Troubleshooting – Conduct feasibility studies, optimize assay parameters, troubleshoot technical challenges, and ensure reproducibility and robustness of experimental workflows.
• Data Analysis & Documentation – Analyze experimental data using appropriate statistical tools; maintain accurate laboratory records; prepare summaries, technical reports, and SOP documentation to support development programs.
• Regulatory & Quality Compliance – Perform work in accordance with company SOPs, quality standards, and applicable regulatory guidelines.
• Cross-Functional Collaboration – Work closely with biology, pharmacology, DMPK, and translational teams to support candidate progression across Tonix’s therapeutic and vaccine pipeline

 

 

 

 

Necessary Skills and Abilities

• Bioanalytical Expertise: Proven track record developing and validating bioanalytical assays for potency, neutralizing antibodies, immunogenicity, and biomarkers.
• Assay Development Skills: Strong background in high-throughput and 384-well cell-based assay design, with applications in drug discovery and translational research
• Hands-on experience with mammalian cell culture; 3D culture and/or organoid systems preferred.
• Technical Skills: Proficiency in qPCR ELISA, MSD, high-content imaging, and automated assay workflows.
• Familiarity with bioprinting systems, CAD design inputs, or digital tissue modeling preferred
• Software Proficiency of data analysis tools (GraphPad Prism, Excel, Python, R, or similar) and advanced bioanalysis/image analysis tools.
• Research Record: Publications and assay development experience that reflect innovation, impact, and strong scientific execution.
• Critical Thinking & Communication: Ability to interpret complex datasets and clearly communicate findings to scientific and non-scientific stakeholders.

Educational and Experience Requirements

• PhD in Biochemistry, Molecular Biology, Cell Biology, bioengineering, or related field.

*Please note that Tonix does not offer sponsorship for this role.

Recruitment & Staffing Agencies

Tonix does not accept agency resumes unless contacted directly by internal Tonix Talent Acquisition. Please do not forward resumes to Tonix employees or any other company location; Tonix is not responsible for any fees related to unsolicited resumes.

Compensation & Benefits

Tonix provides a comprehensive compensation and benefits package which includes:

• Medical, Dental & Vision Insurance, Basic and Voluntary Life and AD&D Insurance, Short- and Long-Term Disability Insurance, Flexible Spending Accounts, Health Savings Account, and Employee Assistance Programs
• Pet Insurance
• Retirement Savings 401k with company match and annual discretionary stock options
• Generous Paid Time Off, Sick Time, & Paid Holidays
• Career Development and Training

Tonix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, genetics, or any other characteristic protected by law.  In addition to federal law requirements, Tonix complies with applicable state and local laws governing nondiscrimination in employment.  This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training.  Tonix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, veteran status, or any other characteristic protected by law.